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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 10
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Research Article

Cytochrome P-450 monooxygenases in insects

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Pages 1077-1092 | Received 16 Jan 1989, Accepted 15 Jun 1989, Published online: 22 Sep 2008
 

Abstract

1. The insect monooxygenase system is involved in the oxidative metabolism of both endogenous and exogenous substrates.

2. Monooxygenases appear to be important in insect growth and development, in adaptation to multiple food plants in phytophagous insects and in pesticide resistence.

3. The genetics, purification and properties of cytochrome P-450 isozymes of the house fly (Musca domestica) are discussed in relation to their role in resistance to xenobiotics.

4. Induction of insect cytochrome P-450 isozymes is discussed in comparison to induction in mammals and with reference to polyphagy.

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