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Abstract
Background. Studies about work stress and the risk of coronary heart disease (CHD) have yielded inconsistent results. This meta-analysis aimed to investigate the association between job strain and the risk of CHD.
Methods. We searched PubMed and Embase databases for studies reporting data on job strain and the risk of CHD. Studies were included if they reported multiple-adjusted relative risk (RR) with 95% confidence interval (CI) with respect to CHD from job strain.
Results. Fourteen prospective cohort studies comprising 232,767 participants were included. The risk of CHD was increased in high-strain (RR 1.26; 95% CI 1.12–1.41) and passive jobs (RR 1.14; 95% CI 1.02–1.29) but not in active jobs (RR 1.09; 95% CI 0.97–1.22), when compared with low-strain group. The increased risk of CHD in high-strain and passive jobs was mainly driven by studies with a follow-up duration of ≥ 10 years. Neither the low-control (RR 1.06; 95% CI 0.93–1.19) nor high-demand (RR 1.13; 95% CI 0.97–1.32) dimension was independently associated with the risk of CHD.
Conclusions. Individuals with high-strain and passive jobs were more likely to experience a CHD event. Intervention programs incorporating individual and organizational levels are crucial for reducing job strain and the risk of CHD.
Acknowledgements
Shuxian Xu and Yuli Huang contributed equally to this work.
Funding: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
Declaration of interest: The authors declare that they have no competing interests.
Supplementary material available online
Supplementary Materials (Supplementary File 1, Supplementary File 2, Supplementary File 3 and Supplementary Figure 1–3) available online at http://informahealthcare.com/doi/abs/10.3109/07853890.2015.1075658.