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Articles

PATTERN OF RELAPSED DISEASE IN CHILDHOOD ALL: Experience from a Single Tertiary Care Center in North India

, MD, , MD, FRCPCH, , MD & , MD
Pages 398-406 | Accepted 01 Dec 2009, Published online: 11 Nov 2009
 

Abstract

The study was designed to determine the pattern of relapsed disease and identify problem areas in management. Relapse occurred in 111 (23.9%) of the boys and 16 (13.0%) of the girls. The majority relapsed while on chemotherapy. Isolated relapse in the marrow and in the CNS was seen in 51 (40.8%) and 24 (18.9%) patients, respectively. Isolated testicular relapse was seen in 17 (15.3%) of the 111 boys who suffered a relapse. Age and TLC at initial presentation and gender in relapsers and nonrelapsers were compared. Multivariate regression analysis showed that gender (p = .03) and TLC (p = .001) were significant predictors of relapse. Relapse of disease while on chemotherapy and high incidence of CNS and testicular relapse indicate the need for reappraisal of treatment protocols.

ACKNOWLEDGMENT

The authors acknowledge the residents and staff of the Advanced Pediatric Center for their invaluable assistance in management of patients with ALL.

Declaration of Interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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