SUCCESSFUL MOBILIZATION WITH AMD3100 AND FILGRASTIM WITH ENGRAFTMENT OF AUTOLOGOUS PERIPHERAL BLOOD STEM CELLS IN A HEAVILY PRETREATED PEDIATRIC PATIENT WITH RECURRENT BURKITT LYMPHOMA

Abstract

The authors report a case of a 13-year-old female with recurrent Burkitt lymphoma who was heavily pretreated with chemotherapy. During chemotherapy for relapse, she developed serious aspergillus infection of the palate and sinuses. Despite 10 μg/kg of filgrastim for 5 days, peripheral blood CD34⁺ cells remained ≤1/μL. Hematopoietic progenitor cells were subsequently successfully mobilized with a combination of AMD3100 and filgrastim without tumor or fungus contamination. After transplantation, the patient achieved complete engraftment without exacerbation of fungal infection. This is the first case report of a pediatric patient with relapsed Burkitt lymphoma with mobilization of hematopoietic progenitor cells by AMD3100 without any adverse reactions.

Keywords :

• AMD3100 (Mozobil, Plerixafor)
• aspergillosis
• Burkitt lymphoma
• hematopoietic progenitor cell mobilization