REGRESSION OF PRIMARY CENTRAL NERVOUS SYSTEM GERMINOMA AFTER DEXAMETHASONE ADMINISTRATION: A Case Report

Stephanie J. SiNeural Tumors Program, Children's Center for Cancer and Blood Diseases, Childrens Hospital Los Angeles, Los Angeles, California, USA

, BS,

Soumen KhatuaNeural Tumors Program, Children's Center for Cancer and Blood Diseases, Childrens Hospital Los Angeles, Los Angeles, California, USACorrespondence[email protected]

, MD,

Girish DhallNeural Tumors Program, Children's Center for Cancer and Blood Diseases, Childrens Hospital Los Angeles, Los Angeles, California, USA

, MD,

Marvin D. NelsonDepartment of Radiology, Childrens Hospital Los Angeles, Los Angeles, California, USA

, MD,

Ignacio Gonzalez-GomezDepartment of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles, Los Angeles, California, USA

, MD &

Jonathan L. FinlayNeural Tumors Program, Children's Center for Cancer and Blood Diseases, Childrens Hospital Los Angeles, Los Angeles, California, USA

, MBChB

Abstract

Childhood central nervous system (CNS) germinoma are highly curable brain tumors characterized pathologically by varying degrees of lymphocytic infiltration. The authors present a case of a CNS germinoma with significant regression in size following surgery and administration of dexamethasone, prior to initiation of chemotherapy or irradiation. The authors speculate the possible mechanism involved in its occurrence. Perioperative corticosteroid administration in patients with CNS germinoma may obfuscate the increase in response demonstrated with various chemotherapy regimens or with irradiation in CNS germinomas.

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REGRESSION OF PRIMARY CENTRAL NERVOUS SYSTEM GERMINOMA AFTER DEXAMETHASONE ADMINISTRATION: A Case Report

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REGRESSION OF PRIMARY CENTRAL NERVOUS SYSTEM GERMINOMA AFTER DEXAMETHASONE ADMINISTRATION: A Case Report

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