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Abstract
Due to the poor survival in high-grade glioma (HGG), secondary solid malignancies (SSM) following pediatric HGG are scarce. The authors present the experience from the HIT-HGG database in Germany, Austria, and Switzerland. Five out of 1228 pediatric HGG patients developed a SSM following a latency of 29–122 months from primary HGG diagnosis. In 4 patients, the SSM may be attributed to previous radiotherapy or a tumor predisposition syndrome, reflected by a markedly increased cumulative incidence rate of SSM in patients with tumor predisposition. Survival was devastating, since none of the patients survived beyond 18 months from SSM diagnosis.
ACKNOWLEDGMENTS
The ongoing support of the Deutsche Kinderkrebsstiftung, Bonn, Germany, is greatly acknowledged. Without this support, performance of clinical trials as well as quality control measures such as central neuropathological and neuroradiological review and a central review of radiotherapy planning would not be possible within the GPOH Pediatric Brain Tumor Network (HIT Network). We also thank all colleagues who contributed patients and their data to the HIT-GBM/HIT-HGG studies. The excellent work of Johannes Wolff and Sabine Wagner within the HIT-GBM trials is thankfully acknowledged.
Declaration Of Interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.