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ALL/Supportive care

Direct Antiglobulin Test Positivity in Children With Acute Lymphoblastic Leukemia at Diagnosis

, , , , , & show all
Pages 490-494 | Received 25 Jun 2015, Accepted 23 Jul 2015, Published online: 18 Sep 2015
 

Abstract

Direct antiglobulin test positivity had been reported in the course of some lymphoproliferative neoplasms. However, there are a few case reports describing direct antiglobulin test (DAT) positivity in children with acute lymphoblastic leukemia (ALL). We herein report 8 patients who had positive DAT among 95 newly diagnosed children with ALL. None of these patients had evidence of hemolysis during the follow-up. An antibody was detected in 2 of 8 patients with positive DAT. These 2 children also had positive indirect antiglobulin test (IAT); an autoantibody that was reactive at 4°C, and an alloantibody (anti E) that was reactive at 37°C was detected. We believe DAT positivity in ALL without significant hemolysis is not a rare disorder, and a need for further prospective studies is apparent.

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