Improved Prognosis for Children with Stage IV Neuroblastoma: High-Dose Melphalan and Autologous Unpurged Marrow Transplantation after Aggressive Surgery and Short Chemotherapy with Cisplatinum and Etoposide

Abstract

A new therapeutic approach was adopted for 13 consecutive patients with stage IV neuroblastoma over 1 year of age admitted to the Children's Hospital, University of Helsinki, between October 1981 and August 1985. Treatment was based on induction, with aggressive, repealed early surgery and a relatively short course of chemotherapy with cisplatinum and etoposide, and on consolidation, with 140-180 mg/m² of melphalan followed by autologous unpurged bone marrow. Induction therapy failed in only 2 of the 13 patients. One of the two was never autografted. So a total of 12 children underwent autologous marrow transplantations, 10 in primary and 1 in secondary remission, and one with residual disease. One patient died in septicemia during postmelphalan pancytopenia, and four patients relapsed 0.3-2.9 years after transplantation. Seven of the original 13 patients (54 %) are well and living in continuous remission 2.3-4.1 (median 2.8) years after diagnosis.

Key Words:

• cisplatinum
• etoposide
• melphalan
• neuroblastoma
• surgery