Hemophagocytosis and Acute Monoblastic Leukemia

L. Russell Department of Haematology, Royal Hospital for Sick Children, 17 Millerfield Place, Edinburgh, EH9 1LF, Scotland

N. J. Shaw Department of Haematology, Royal Hospital for Sick Children, 17 Millerfield Place, Edinburgh, EH9 1LF, Scotland

O. B. Eden Department of Haematology, Royal Hospital for Sick Children, 17 Millerfield Place, Edinburgh, EH9 1LF, Scotland

Abstract

A 16-month-oldgirl presented with hepatosplenomegaly and pancytopenia. Bone marrow aspiration showed a florid increase in macrophages with marked hemophagocytosis. She subsequently improved spontaneously with no therapeutic intervention, but 2 months later presented with frank acute monoblastic leukemia. This case illustrates the difficulties in classifying malignancies of the monocyte-macrophage lineage and how hemophagocytosis can be the presenting feature of a range of diseases.

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Hemophagocytosis and Acute Monoblastic Leukemia

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Hemophagocytosis and Acute Monoblastic Leukemia

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