Central Nervous System Disease in Childhood Acute Lymphoblastic Leukemia: Prognostic Factors and Results of Treatment

A. Kreuger Department of Pediatrics, University Hospital, S-751 85, Uppsala, Sweden

S. Garwicz Department of Pediatrics, University of Lund, S-221 85, Lund, Sweden

H. Hertz Department of Pediatrics, Rigshospitalet, DK-2100, Copenhagen, Denmark

C. Jonmundsson Department of Pediatrics, Landspitalinn, Reykjavik, Iceland

M. Latining Department of Pediatrics and Diagnostic Radiology, University of Oulu, 90220, Oulu, Finland

S. O. Lie Pediatric Research Institute, National Hospital of Norway, Oslo, Norway

P. J. Moe Department of Paediatrics, University of Trondheim, N-7000, Trondheim, Norway

T. T. Salmi Department of Pediatrics, ravi, Århus C, Denmark

H. Schröder Department of Pediatrics, ravi, SF-20520, Turku, Finland

M. A. Siimes Children's Hospital, University of Helsinki, Helsinki, Finland, and Children's Hospital, University of Kuopio, SF-70201, Kuopio, Finland

F. Wesenberg Department of Pediatrics, Haukeland University Clinic, N-5016, Bergen, Norway

M. Yssing Department of Pediatrics, Rigshospitalet, Copenhagen, Denmark

L. Åhström Department of Pediatrics, Karolinska Hospital, S-104 101, Stockholm, Sweden

G. Gustafsson Department of Pediatrics, Central Hospital, S-831 85, Östersund, Sweden

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Abstract

(years) revealed that isolated CNS relapse had occurred in 70 children (9.0%). Of these 70 patients, 12 out of 142 children (8.5%) had initially received irradiation and 58 out of 628 children (9.2%) only chemotherapy as CNS-prophylaxis. There was a significant higher risk for boys (12%) than for girls (6%) to relapse in the CNS compartment. Unfavorable prognostic factors for survival after isolated CNS relapse were short duration of first remission and male sex. In high-risk patients after an isolated CNS relapse, there was no difference in prognosis related to treatment with or without irradiation as initial CNS prophylaxis.

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Central Nervous System Disease in Childhood Acute Lymphoblastic Leukemia: Prognostic Factors and Results of Treatment

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Central Nervous System Disease in Childhood Acute Lymphoblastic Leukemia: Prognostic Factors and Results of Treatment

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