Granulocyte Colony-Stimulating Factor Associated Leukocytoclastic Vasculitis Mimicking Henoch-Schonlein Purpura

Abstract

Human granulocyte colony-stimulating factor (G-CSF) is one of the hematopoietic growth factors that is used for the reduction of neutropenia in cancer patients receiving myelosuppressive chemotherapy and in patients with congenital and cyclic neutropenia. Adverse effects associated with the use of G-CSF, such as bone pain, are usually mild and transient. We report a more serious and disturbing association, leukocytoclastic vasculitis, which manifested as a cutaneous purpuric lesion with painful joints and mimicked Henoch-Schönlein purpura.