Abstract
Neuroblastoma is a common childhood malignant tumor having a very poor prognosis because of its very invasive characteristics. However, the central nervous system (CNS) is usually not affected, with the exception of the disseminating stage. A case with a mediastinal neuroblastoma having a solitary relapse in the CNS after completing therapy is reported here. A lumbar puncture revealed neuroblastoma cell clumps in the cerebrospinal fluid (CSF). This is a rare condition referred to as “meningeal neuroblastoma,” and aggressive therapy, including the intrathecal administration of nimustine (ACNU), was effective in removing the clump from the CSF.