Transient Aplastic Crisis in a Leukemic Child Caused by Parvovirus B19 Infection

Vladimír Mihál Department of Paediatrics, Faculty of Medicine, Palacky University, Olomouc, Czech Republic

Jaroslav Dušek Institute of Pathology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic

Marián Hajdúch Institute of Immunology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic

Bernard J. Cohen Central Public Health Laboratory, Virus Reference Division, London, Great Britain

Helena Fingerová Department of Gynaecology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic

Jaroslav Veselý Institute of Pathophysiology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic

Abstract

Acute parvovirus B19 infection was confirmed in an 8-year-old girl with acute lymphoblastic leukemia on maintenance therapy by electron microscopy, DNA, and serological techniques. Clinical manifestations were typical of severe anemia, fever, leukopenia, and thrombocytopenia. Increased levels of serum erythropoietin were detected in the course of the infection. The patient's recovery was supported by corticosteroids, red blood cell transfusions, G-CSF, and commercial immunoglobulin preparations.

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Transient Aplastic Crisis in a Leukemic Child Caused by Parvovirus B19 Infection

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Transient Aplastic Crisis in a Leukemic Child Caused by Parvovirus B19 Infection

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