Elevated Cytokine Levels in Synovial Fluid of Rheumatoid Arthritis Correlates with the Presence of Cytomegalovirus Genome

T. Murayama Department of Microbiology, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, 920-02, Japan

N. Tsuchiya Department of Medicine and Physical Therapy, University of Tokyo, Faculty of Medicine, Tokyo, 113, Japan

F. Jisaki Department of Pathology, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, 920-02, Japan

M. Ozaki Division of Human Genetics, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, 920-02, Japan

D. Sakamuro Department of Microbiology, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, 920-02, Japan

K. Hirai Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 113, Japan

S. Shimizu Internal Medicine, Division of Hematology and Immunology, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, 920-02, Japan

K. Ito Department of Medicine and Physical Therapy, University of Tokyo, Faculty of Medicine, Tokyo, 113, Japan

K. Matsushima Department of Pharmacology, Cancer Research Institute, Kanazawa University, Kanazawa, 920, Japan

T. Furukawa Department of Microbiology, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, 920-02, Japan

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Abstract

Synovial fluid aspirated from 34 patients with symptomatic rheumatoid arthritis (RA) was evaluated for the presence of human cytomegalovirus (CMV) genomic material using polymerase chain reaction (PCR), and for levels of interleukin 8 (IL-8) and IL-6 using enzyme-linked immunoadsorbence assay. IL-8 and IL-6 levels were significantly higher in CMV DNA-positive RA patients than CMV DNA-negative RA patients and at least 10-fold higher than in both corresponding control groups of patients with osteoarthritis (OA). These findings suggest an association between elevated IL-8 and IL-6 levels and the presence of the CMV genome in RA patients.

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Elevated Cytokine Levels in Synovial Fluid of Rheumatoid Arthritis Correlates with the Presence of Cytomegalovirus Genome

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Elevated Cytokine Levels in Synovial Fluid of Rheumatoid Arthritis Correlates with the Presence of Cytomegalovirus Genome

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