A qualitative description of the peptide sharing between poliovirus and Homo sapiens

Abstract

In a companion paper, we reported that pentapeptides from human poliovirus 1, Mahoney strain, occur repeatedly in human proteins for a total of more than 18,000 overlaps. In the present study, we describe the distribution of the polio pentapeptides throughout biochemical pathways and networks characterizing functions and tissues in the human host. The present study might be of help to better define the poliovirus-host relationships as well as for designing peptide modules with anti-polio activity.

Keywords::

• Poliovirus polyprotein
• human proteome
• peptide commonality
• neural pathways
• axon guidance

Acknowledgments

G.C., G.N., S.L.B., and C.F. performed the computational analyses. A.P.D. and A.N.P. collaborated to the project discussion and definition. D.K. proposed the original idea, supervised the work, interpreted the data and wrote the paper. All authors discussed and approved the paper. G.C. holds a research scholarship. G.N., S.L.B., and C.F. are PhD students of the course “Analytical Morphometry and Models of Molecular Medicine”.

Declaration of interest

Partial funding for this work was provided by the Ministry of University and Research of Italy (60%).