Daily exposure to inhomogeneous static magnetic field significantly reduces blood glucose level in diabetic mice

Abstract

Purpose: The present study was designed to reveal, whether the 30 min daily full body exposure of mice to an inhomogeneous static magnetic field (SMF) has a statistically significant effect on diabetic neuropathy.

Materials and methods: Three different doses (100, 150, or 200 mg/kg) of streptozotocin (STZ) were administered intraperitoneally in groups of mice to induce diabetes. Body weight, blood glucose level and the nociceptive temperature threshold of mice were monitored for a period of 12 weeks. The group treated with 200 mg/kg i.p. STZ produced manifest diabetic neuropathy. Results were compared to non-treated (no SMF, no STZ) and SMF exposure without STZ-treatment group (SMF, no STZ) group. The inhomogeneous SMF was in the range of 2.8–476.7 mT peak-to-peak magnetic flux density.

Results: Whereas SMF exposure did not seem to affect body weight and nociceptive temperature threshold, it statistically significantly (p < 0.001) reduced blood glucose level in the 200 mg/kg STZ (n = 6) group.

Conclusions: Daily SMF exposure repeated for several weeks is protective against the development of high blood glucose level in diabetic mice.

Keywords:

• neuropathy
• diabetes
• neuropathia diabetica
• static magnetic field (SMF)
• mouse
• streptozotocin (STZ)

Acknowledgements

This work was supported by the Hungarian National Office for Research and Technology (Innocsekk project KM_CSEKK-2006-00249).

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.