Metabolic regulation via enzyme filamentation

Abstract

Determining the mechanisms of enzymatic regulation is central to the study of cellular metabolism. Regulation of enzyme activity via polymerization-mediated strategies has been shown to be widespread, and plays a vital role in mediating cellular homeostasis. In this review, we begin with an overview of the filamentation of CTP synthase, which forms filamentous structures termed cytoophidia. We then highlight other important examples of the phenomenon. Moreover, we discuss recent data relating to the regulation of enzyme activity by compartmentalization into cytoophidia. Finally, we hypothesize potential roles for enzyme filament formation in the regulation of metabolism, development and disease.

Keywords:

• CTP synthase
• cytoophidium
• IMP dehydrogenase
• intracellular compartmentation
• metabolism

Disclosure statement

The authors declare no conflict of financial interest. The study of cytoophidia in the Liu lab was supported by UK Medical Research Council.