Rheological evaluation of wet masses for the preparation of pharmaceutical pellets by capillary and rotational rheometers

Abstract

The rheological properties of wet powder masses used in the preparation of pharmaceutical pellets by extrusion/spheronization were evaluated utilizing capillary and rotational rheometers. A ram extruder was used as a capillary rheometer to construct flow and viscosity curves for each wet mass under different extrusion rates and die geometry. As a result, shear thinning behavior was observed for all wet masses. Among the considered rheological models Power Law and Herschel-Bulkley models fitted well with the experimental results. For the majority of the wet masses, water separation and migration occurred during extrusion which led to uneven water content in the extrudate. The effect of extrusion condition including extrusion speed, die geometry and water content on the occurrence of water separation was investigated and the surface quality of the extrudates was compared. In addition, dynamic rheometry tests were done by a parallel plate rheometer to investigate the viscoelastic properties of the wet masses. The frequency sweep tests showed that as water content of the wet masses decreases storage (G′) and loss modulus (G″) increase. The storage modulus values were much higher than those of the loss modulus showing dominated elastic rather than viscous behavior for the wet masses at low deformation rates.

Keywords::

• Extrusion
• spheronization
• microcrystalline cellulose
• ram extruder
• parallel plate rheometer
• oscillatory measurements