Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice

Abstract

Streptozotocin (STZ)-induced diabetes in mice progresses with decreased desaturase activities and alterations in the metabolism of essential fatty acids (EFA). Objectives: Based on our previous studies with soybean oil that ameliorated the STZ damage in mice, we tested here the accountability of its main EFA components, i.e. linoleic acid (LA) and alpha linolenic acid (ALA), in the prevention of pancreas damage and Δ6 desaturase decrease. Materials and methods: Seven days after injection with STZ and EFA gavage, ICR mice were sacrificed. Plasma glucose and insulin levels, pancreas histology and liver fatty acid desaturases were analysed. Results: EFA reduced pancreas damage, insulin and glucose plasma levels and restored Δ6 desaturase activity and mRNA expression levels. Discussion: By reducing pancreas damage, EFA ameliorated insulin levels, Δ6 desaturase and fatty acid metabolism. LA further enhanced Fads2 promoter activity. Conclusion: EFA ameliorate STZ induced diabetes in mice.

• Alpha linolenic acid
• fatty acid desaturases
• linoleic acid
• pancreas
• type 1 diabetes mellitus

Acknowledgements

The Minerva Center for Cholesterol Gallstones Research and Lipid Metabolism in Liver and the late Prof. Tuvia Gilat and Fred Konikoff allowed the use of its facilities.