Some biologically active oxovanadium(IV) complexes of triazole derived Schiff bases: their synthesis, characterization and biological properties

Abstract

A series of biologically active oxovanadium(IV) complexes of triazole derived Schiff bases L₁–L₅ have been synthesized and characterized by their physical, analytical, and spectral data. The synthesized ligands potentially act as bidentate, in which the oxygen of furfural and nitrogen of azomethine coordinate with the oxovanadium atom to give a stoichiometry of vanadyl complexes 1:2 (M:L) in a square-pyramidal geometry. In vitro antibacterial and antifungal activities on different species of pathogenic bacteria (E. coli, S. flexneri, P. aeruginosa, S. typhi, S. aureus, and B. subtilis) and fungi (T. longifusus, C. albicans, A. flavus, M. canis, F. solani, and C. glabrata) have been studied. All compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against most of the fungal strains. The brine shrimp bioassay was also carried out to check the cytotoxicity of coordinated and uncoordinated synthesized compounds.

Keywords::

• Triazole Schiff base
• oxovanadium(IV) complexes
• antibacterial
• antifungal

Acknowledgement

One of the authors (S.H.S.) is thankful to the Higher Education Commission (HEC), Government of Pakistan, for an award to carry out this research. We are also indebted to the HEJ Research Institute of Chemistry, University of Karachi, Pakistan, for providing assistance in recording NMR and mass spectra, and for help in carrying out antibacterial, antifungal, and brine shrimp bioassays.

Declaration of interest

The authors report no conflict of interest and are responsible for the contents and writing of the paper.