Abstract
Triazole derived Schiff bases and their metal complexes (cobalt(II), copper(II), nickel(II), and zinc(II)) have been prepared and characterized using IR, 1H and 13C NMR, mass spectrometry, magnetic susceptibility and conductivity measurements, and CHN analysis data. The structure of L2, N-[(5-methylthiophen-2-yl)methylidene]-1H-1,2,4-triazol-3-amine, has also been determined by the X-ray diffraction method. All the metal(II) complexes showed octahedral geometry except the copper(II) complexes, which showed distorted octahedral geometry. The triazole ligands and their metal complexes have been screened for their in vitro antibacterial, antifungal, and cytotoxic activity. All the synthesized compounds showed moderate to significant antibacterial activity against one or more bacterial strains. It is revealed that all the synthesized complexes showed better activity than the ligands, due to coordination.
Acknowledgements
We also thankful to the HEJ Research Institute of Chemistry, University of Karachi, Pakistan, for providing help in recording NMR and mass spectra and also the antibacterial and antifungal assays.
Declaration of interest
One of the authors (M.H.) is grateful to the Higher Education Commission (HEC), Government of Pakistan, for an award to carry out this research.