Synthesis of new 8(S)-HETE analogs and their biological evaluation as activators of the PPAR nuclear receptors

Abstract

Structural modifications around 8-HETE (8-hydroxyeicosatetraenoic acid), a natural agonist of the PPAR (peroxisome proliferator-activated receptor) nuclear receptors have led previously to the identification of a promising analog, the quinoline S 70655. Series of novel quinoline or benzoquinoline derivatives were designed through the modification of this lead. Variations of the nature of the aromatic core and of the side chains were carried out. The SAR studies indicated the high sensitivity of the upper acid chain to modifications as well as the strong effect of the length and size of the lipophilic side chain. They afforded several new promising PPARα/γ dual agonists with a high PPARα activity in vitro.

Keywords::

• PPARs
• dual agonists
• benzoquinoline
• quinoline
• 3-chloro-2-quinolinecarboxaldehyde