Abstract
In this study, a series of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues were synthesized and evaluated for antimycobacterial activity against Mycobacterium tuberculosis (MTB) H37Rv and isoniazid resistant M. tuberculosis (INHR-MTB). All the newly synthesized compounds were showing moderate to high inhibitory activities. The compound 6,7-dimethoxy-3-(4-chloro phenyl)-4H-indeno[1,2-c]isoxazole (4b) was found to be the most promising compound, active against MTB H37Rv and INHR-MTB with minimum inhibitory concentrations of 0.22 and 0.34 μM.
Acknowledgements
The authors thank Institute for Research in Molecular Medicine, Universiti of Sains Malysia, Pennag, Malaysia and Alwar Pharmacy College, Alwar, Rajasthan, India, for providing research facilities.
Declaration of interest
The authors declare no conflicts of interest.