Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 26, Issue 4 (2011)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 26, Issue 4 (2011)

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Original Article

Article
Pancreatic lipase inhibition activity of trilactone terpenes of Ginkgo biloba
Yasser Bustanji, Ihab M. Al-Masri, Mohammad Mohammad, Mohammad Hudaib, Khaled Tawaha, Hamada Tarazi & Hatim S. AlKhatib
Pages: 453-459
Published online: 28 Oct 2010
AbstractforPancreatic lipase inhibition activity of trilactone terpenes of Ginkgo biloba | Full Text | References | PDF (783.1 KB)
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Article
The evaluation of novel natural products as inhibitors of human glutathione transferase P1-1
Stanley Mukanganyama, Merhatibeb Bezabih, Metuno Robert, Boneventure T. Ngadjui, Gilbert F. W. Kapche, Francois Ngandeu & Berhanu Abegaz
Pages: 460-467
Published online: 28 Oct 2010
AbstractforThe evaluation of novel natural products as inhibitors of human glutathione transferase P1-1 | Full Text | References | PDF (708.5 KB)
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Article
Antimicrobial activities of Conyzolide and Conyzoflavone from Conyza canadensis
Mohammad Shakirullah, Hanif Ahmad, Muhammad Raza Shah, Imtiaz Ahmad, Muhammad Ishaq, Nematullah Khan, Amir Badshah & Inamullah Khan
Pages: 468-471
Published online: 05 Nov 2010
AbstractforAntimicrobial activities of Conyzolide and Conyzoflavone from Conyza canadensis | Full Text | References | PDF (587 KB)
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Article
Synthesis, characterization, antiamoebic activity and cytotoxicity of new pyrazolo[3, 4-d]pyrimidine-6-one derivatives
Faisal Hayat, Attar Salahuddin & Amir Azam
Pages: 472-479
Published online: 05 Nov 2010
AbstractforSynthesis, characterization, antiamoebic activity and cytotoxicity of new pyrazolo[3, 4-d]pyrimidine-6-one derivatives | Full Text | References | PDF (821.1 KB)
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Article
Urease inhibitors from Indigofera gerardiana Wall.
Shafiq Ahmad Tariq, Muhammad Nisar Ahmad, Obaidullah, Ajmal Khan, Muhammad Iqbal Choudhary, Waqar Ahmad & Manzoor Ahmad
Pages: 480-484
Published online: 11 Nov 2010
AbstractforUrease inhibitors from Indigofera gerardiana Wall. | Full Text | References | PDF (619.8 KB)
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Article
Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors
Jaroslav Šebestík, Sérgio M. Marques, Pedro L. Falé, Susana Santos, Daniela M. Arduíno, Sandra M. Cardoso, Catarina R. Oliveira, M. Luísa M. Serralheiro & M. Amélia Santos
Pages: 485-497
Published online: 11 Nov 2010
AbstractforBifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors | Full Text | References | PDF (882.9 KB)
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Article
Synthesis and in vitro microbiological evaluation of novel diethyl 6,6′-(1,4-phenylene)bis(4-aryl-2-oxo-cyclohex-3-enecarboxylates)
V. Kanagarajan, M. R. Ezhilarasi & M. Gopalakrishnan
Pages: 498-505
Published online: 22 Mar 2011
AbstractforSynthesis and in vitro microbiological evaluation of novel diethyl 6,6′-(1,4-phenylene)bis(4-aryl-2-oxo-cyclohex-3-enecarboxylates) | Full Text | References | PDF (626.3 KB)
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Article
Design, synthesis, and biological activity of thiazole derivatives as novel influenza neuraminidase inhibitors
Yu Liu, Lei Zhang, Jianzhi Gong, Hao Fang, Ailin Liu, Guanhua Du & Wenfang Xu
Pages: 506-513
Published online: 14 Dec 2010
AbstractforDesign, synthesis, and biological activity of thiazole derivatives as novel influenza neuraminidase inhibitors | Full Text | References | PDF (1.1 MB)
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Article
Apixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma
Joseph M. Luettgen, Robert M. Knabb, Kan He, Donald J. P. Pinto & Alan R. Rendina
Pages: 514-526
Published online: 20 Dec 2010
AbstractforApixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma | Full Text | References | PDF (958.8 KB)
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Article
Synthesis of 1,2,4-triazole derivatives containing benzothiazoles as pharmacologically active molecule
Navin B. Patel & Imran H. Khan
Pages: 527-534
Published online: 30 Jun 2011
AbstractforSynthesis of 1,2,4-triazole derivatives containing benzothiazoles as pharmacologically active molecule | Full Text | References | PDF (612.1 KB)
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Article
Discovery of potential pancreatic cholesterol esterase inhibitors using pharmacophore modelling, virtual screening, and optimization studies
Shalini John, Sundarapandian Thangapandian, Sugunadevi Sakkiah & Keun Woo Lee
Pages: 535-545
Published online: 14 Dec 2010
AbstractforDiscovery of potential pancreatic cholesterol esterase inhibitors using pharmacophore modelling, virtual screening, and optimization studies | Full Text | References | PDF (1.3 MB)
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Article
Thiazolidin-4-one and hydrazone derivatives of capric acid as possible anti-inflammatory, analgesic and hydrogen peroxide-scavenging agents
Archana Sharma, Vipin Kumar, Sandeep Jain & Prabodh Chander Sharma
Pages: 546-552
Published online: 20 Dec 2010
AbstractforThiazolidin-4-one and hydrazone derivatives of capric acid as possible anti-inflammatory, analgesic and hydrogen peroxide-scavenging agents | Full Text | References | PDF (606.9 KB)
  • 915 Views
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Article
Molecular engineering of a small trypsin inhibitor based on the binding loop of horsegram seed Bowman-Birk inhibitor
Deepa G. Muricken & Lalitha R. Gowda
Pages: 553-560
Published online: 20 Dec 2010
AbstractforMolecular engineering of a small trypsin inhibitor based on the binding loop of horsegram seed Bowman-Birk inhibitor | Full Text | References | PDF (759.3 KB)
  • 710 Views
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Article
Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 2-{4-[4-(2,5-disubstituted thiazol-4-yl)phenylethyl]piperazin-1-yl}-1,8-naphthyridine-3-carbonitriles as atypical antipsychotic agents
Kondapalli Venkata Gowri Chandra Sekhar, Vajja Samabasiva Rao, Winnie Deuther-Conrad, Aravalli Satish Reddy, Peter Brust & Mutyala Murali Krishna Kumar
Pages: 561-568
Published online: 20 Dec 2010
AbstractforDesign, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 2-{4-[4-(2,5-disubstituted thiazol-4-yl)phenylethyl]piperazin-1-yl}-1,8-naphthyridine-3-carbonitriles as atypical antipsychotic agents | Full Text | References | PDF (745.2 KB)
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Article
Novel oxazine skeletons as potential antiplasmodial active ingredients: Synthesis, in vitro and in vivo biology of some oxazine entities produced via cyclization of novel chalcone intermediates
Vandana Tiwari, Jyotsna Meshram, Parvez Ali, Javed Sheikh & Umanath Tripathi
Pages: 569-578
Published online: 20 Dec 2010
AbstractforNovel oxazine skeletons as potential antiplasmodial active ingredients: Synthesis, in vitro and in vivo biology of some oxazine entities produced via cyclization of novel chalcone intermediates | Full Text | References | PDF (724.5 KB)
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Research Article

Article
Oxamic acid analogues as LDH-C4-specific competitive inhibitors
Lorena Rodríguez-Páez, Miguel Angel Chena-Taboada, Arturo Cabrera-Hernández, Joaquín Cordero-Martínez & Carlos Wong
Pages: 579-586
Published online: 25 Mar 2011
AbstractforOxamic acid analogues as LDH-C4-specific competitive inhibitors | Full Text | References | PDF (663.3 KB)
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Short Communications

Evaluation of the inhibitory potential of five squaric acid derivatives against pancreatic lipase
Zorka Bobcheva, Diana Zhiryakova & Maya Guncheva
Pages: 587-591
Published online: 25 Mar 2011
AbstractforEvaluation of the inhibitory potential of five squaric acid derivatives against pancreatic lipase | Full Text | References | PDF (627.4 KB)
  • 635 Views
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Inhibition of lipoxygenase (LOX) and anticancer activity caused by gold(I) mixed ligands complexes of triphenylphosphine and thioamides
E. Georgiou, A. Metsios, N. Kourkoumelis, S. Karkabounas, K. Charalabopoulos, A. Badeka & S.K. Hadjikakou
Pages: 592-597
Published online: 19 Nov 2010
AbstractforInhibition of lipoxygenase (LOX) and anticancer activity caused by gold(I) mixed ligands complexes of triphenylphosphine and thioamides | Full Text | References | PDF (906 KB)
  • 618 Views
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Antimycobacterial activity: synthesis of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues
Mohamed Ashraf Ali, Rusli Ismail, Tan Soo Choon, Suresh Pandian & Mohamed Zaheen Hassan Ansari
Pages: 598-602
Published online: 30 Jun 2011
AbstractforAntimycobacterial activity: synthesis of novel 3-(substituted phenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues | Full Text | References | PDF (605.6 KB)
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