Synthesis of 1,2,4-triazole derivatives containing benzothiazoles as pharmacologically active molecule

Abstract

In attempt to make significant pharmacologically active molecule, we report here the synthesis and in vitro antimicrobial and antitubercular activity of various series of 3-(3-pyridyl)-5-(4-nitrophenyl)-4-(N-substituted-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole. The antimicrobial activity of title compounds were examined against two Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), two Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), and three fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) using the broth microdilution method and antitubercular activity H₃₇Rv using Lowenstein-Jensen agar method.

Keywords::

• 1,2,4-Triazole
• antimicrobial activity
• antitubercular activity

Acknowledgements

The authors are thankful to Veer Narmad South Gujarat University for providing necessary facilities and research fellowship. We also thank SAIF Lucknow for elemental analysis and SAIF Chandigarh for spectral analysis of the compounds and D. Rajani, Microbial Laboratory, Surat, for antimicrobial and antimycobacterial activity.

Declaration of interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article.