Abstract
A new series of biologically active thienyl derived triazole Schiff bases and their oxovanadium(IV) complexes have been synthesized and characterized on the basis of physical (m.p., magnetic susceptibility and conductivity), spectral (IR, 1H and 13C NMR, electronic and mass spectrometry) and microanalytical data. All the Schiff base ligands and their oxovanadium(IV) complexes have been subjected to in vitro antibacterial activity against four Gram-negative (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella enterica serover typhi) and two Gram-positive (Staphylococcus aureus and Bacillus subtilis) bacterial strains and, for in vitro antifungal activity against Trichophyton longifucus, Candida albican, Aspergillus flavus, Microscopum canis, Fusarium solani and Candida glabrata. Brine shrimp bioassay was also carried out to check the cytotoxic nature of these compounds.
Acknowledgment
One of the authors (SHS) is grateful to Higher Education Commission (HEC), Government of Pakistan for the award of scholarship to carry out this research. We are also indebted to HEJ Research Institute of Chemistry, University of Karachi, Pakistan, for providing their help in taking the NMR, mass spectra, antibacterial, antifungal and brine shrimp bioassays.
Declaration of interest
The authors report no conflict of interest and are responsible for the contents and writing of the paper.