Abstract
Several 2,5-disubstituted-1,3,4-oxadiazoles (4a–f) and 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles (7a–f) were synthesized and characterized by elemental analyses and spectral data. These compounds were screened for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities. Compound 7c showed excellent anti-inflammatory and remarkable analgesic activity with reduced ulcerogenic and lipid peroxidation activity when compared with ibuprofen.
Acknowledgements
The authors are thankful to the Jamia Hamdard, New Delhi for providing research facilities. They are also thankful to IIT, New Delhi for providing the 1H NMR and 13C NMRspectra. Special thanks to Prof. M.S.Y. Khan, Prof. Emeritus, Jamia Hamdard, New Delhi for his encouragement and blessings.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.