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Abstract
Beta-carbonic anhydrases (β-CAs) have been recently reported to be present in many protozoan and metazoan species, whereas it is absent in mammals. In this review, we introduce β-CA from Drosophila melanogaster as a model enzyme for pesticide development. These enzymes can be targeted with various enzyme inhibitors, which can have deleterious effects on pathogenic and other harmful organisms. Therefore, β-CAs represent a new potential target to fight against Dipteran vectors and pests relevant to medicine, veterinary medicine, and agriculture.
Declaration of interest
The authors declare that they have no competing interests.
To perform these studies, RZE received a scholarship support from the Ministry of Science, Research and Technology, and National Institute of Genetic Engineering and Biotechnology of Islamic Republic of Iran. This study was also funded by Finnish Cultural Foundation (HB), Sigrid Juselius Foundation (SP), Jane and Aatos Erkko Foundation (SP), and Competitive Research Funding of the Tampere University Hospital (SP).
Authors' contributions
All authors participated in the design of the study. RZE carried out the bioinformatics searches including blast searches, MSA and prediction of subcellular localization. RZE prepared the first version of the manuscript. All authors participated in writing further versions and read and approved the final manuscript.