Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 30, Issue 3 (2015)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 30, Issue 3 (2015)

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Research Article

Article
N-ω-chloroacetyl-l-ornithine, a new competitive inhibitor of ornithine decarboxylase, induces selective growth inhibition and cytotoxicity on human cancer cells versus normal cells
Miriam Marlene Medina-Enríquez, Verónica Alcántara-Farfán, Leopoldo Aguilar-Faisal, José Guadalupe Trujillo-Ferrara, Lorena Rodríguez-Páez & Alba Laura Vargas-Ramírez
Pages: 345-353
Published online: 18 Jun 2014
AbstractforN-ω-chloroacetyl-l-ornithine, a new competitive inhibitor of ornithine decarboxylase, induces selective growth inhibition and cytotoxicity on human cancer cells versus normal cells | Full Text | References | PDF (364.8 KB)
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Article
In vitro and in vivo antitumor activity of the halogenated boroxine dipotassium-trioxohydroxytetrafluorotriborate (K2[B3O3F4OH])
Sinisa Ivankovic, Ranko Stojkovic, Zoran Galic, Borivoj Galic, Jelena Ostojic, Maja Marasovic & Mladen Milos
Pages: 354-359
Published online: 18 Jun 2014
AbstractforIn vitro and in vivo antitumor activity of the halogenated boroxine dipotassium-trioxohydroxytetrafluorotriborate (K2[B3O3F4OH]) | Full Text | References | PDF (568.3 KB)
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Original Article

Article
Antibacterial, antioxidant and hypoglycaemic effects of Thymus capitatus (L.) Hoffmanns. et Link leaves' fractions
Liliana Iauk, Rosaria Acquaviva, Silvana Mastrojeni, Andrea Amodeo, Michela Pugliese, Monica Ragusa, Monica R. Loizzo, Francesco Menichini & Rosa Tundis
Pages: 360-365
Published online: 17 Jul 2014
AbstractforAntibacterial, antioxidant and hypoglycaemic effects of Thymus capitatus (L.) Hoffmanns. et Link leaves' fractions | Full Text | References | PDF (153.4 KB)
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Research Article

Article
Biochemical characterization of recombinant β-carbonic anhydrase (PgiCAb) identified in the genome of the oral pathogenic bacterium Porphyromonas gingivalis
Sonia Del Prete, Daniela Vullo, Viviana De Luca, Zeid AlOthman, Sameh M. Osman, Claudiu T. Supuran & Clemente Capasso
Pages: 366-370
Published online: 17 Jul 2014
AbstractforBiochemical characterization of recombinant β-carbonic anhydrase (PgiCAb) identified in the genome of the oral pathogenic bacterium Porphyromonas gingivalis | Full Text | References | PDF (280.5 KB)
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Article
Synthesis of new isoxazoline derivatives from harmine and evaluation of their anti-Alzheimer, anti-cancer and anti-inflammatory activities
Insaf Filali, Jalloul Bouajila, Mansour Znati, Fatima Bousejra-El Garah & Hichem Ben Jannet
Pages: 371-376
Published online: 28 Jul 2014
AbstractforSynthesis of new isoxazoline derivatives from harmine and evaluation of their anti-Alzheimer, anti-cancer and anti-inflammatory activities | Full Text | References | PDF (220.7 KB)
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Article
Synthesis and evaluation of N-heteroarylsubstituted triazolosulfonamides as carbonic anhydrase inhibitors
Ahmet Balci, Mustafa Arslan, Arleta Rifati Nixha, Cigdem Bilen, Adem Ergun & Nahit Gençer
Pages: 377-382
Published online: 28 Jul 2014
AbstractforSynthesis and evaluation of N-heteroarylsubstituted triazolosulfonamides as carbonic anhydrase inhibitors | Full Text | References | PDF (216.6 KB)
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Article
Synthesis and biological evaluation of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one and its aminomethyl derivatives
Kadir Ozden Yerdelen, Halise Inci Gul, Hiroshi Sakagami & Naoki Umemura
Pages: 383-388
Published online: 28 Jul 2014
AbstractforSynthesis and biological evaluation of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one and its aminomethyl derivatives | Full Text | References | PDF (230.5 KB) | Supplemental
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Article
Synthesis and biological evaluation of 5-benzylidenerhodanine-3-acetic acid derivatives as AChE and 15-LOX inhibitors
Negah Shafii, Mehdi Khoobi, Mohsen Amini, Amirhossein Sakhteman, Hamid Nadri, Alireza Moradi, Saeed Emami, Ebrahim Saeedian Moghadam, Alireza Foroumadi & Abbas Shafiee
Pages: 389-395
Published online: 22 Jun 2015
AbstractforSynthesis and biological evaluation of 5-benzylidenerhodanine-3-acetic acid derivatives as AChE and 15-LOX inhibitors | Full Text | References | PDF (1.5 MB)
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Article
A convenient synthesis and molecular modeling study of novel pyrazolo[3,4-d]pyrimidine and pyrazole derivatives as anti-tumor agents
Ibrahim F. Nassar, Saad R. Atta-Allah & Abdel-Sattar S. Hamad Elgazwy
Pages: 396-405
Published online: 28 Jul 2014
AbstractforA convenient synthesis and molecular modeling study of novel pyrazolo[3,4-d]pyrimidine and pyrazole derivatives as anti-tumor agents | Full Text | References | PDF (679.3 KB)
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Article
Synthesis and cycloxygenase inhibitory properties of new naphthalene-methylsulfonamido, naphthalene-methylsulfonyl and tetrahydronaphthalen-methylsulfonamido compounds
Susanna Nencetti, Lidia Ciccone, Armando Rossello, Elisa Nuti, Claudio Milanese & Elisabetta Orlandini
Pages: 406-412
Published online: 04 Aug 2014
AbstractforSynthesis and cycloxygenase inhibitory properties of new naphthalene-methylsulfonamido, naphthalene-methylsulfonyl and tetrahydronaphthalen-methylsulfonamido compounds | Full Text | References | PDF (316.1 KB)
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Article
Synthesis and pro-apoptotic effects of new sulfonamide derivatives via activating p38/ERK phosphorylation in cancer cells
Ahmet Cumaoglu, Serkan Dayan, Asli Ozge Agkaya, Zehra Ozkul & Nilgun Kalaycioglu Ozpozan
Pages: 413-419
Published online: 08 Sep 2014
AbstractforSynthesis and pro-apoptotic effects of new sulfonamide derivatives via activating p38/ERK phosphorylation in cancer cells | Full Text | References | PDF (1 MB) | Supplemental
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Article
Chromatographic evaluation and QSAR optimization for benzoic acid analogues against carbonic anhydrase III
Muhammed Alzweiri, Qosay Al-Balas & Yusuf Al-Hiari
Pages: 420-429
Published online: 28 Jul 2014
AbstractforChromatographic evaluation and QSAR optimization for benzoic acid analogues against carbonic anhydrase III | Full Text | References | PDF (2.2 MB)
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Original Article

Article
New series of sulfonamides containing amino acid moiety act as effective and selective inhibitors of tumor-associated carbonic anhydrase XII
Mariangela Ceruso, Marco Bragagni, Zeid AlOthman, Sameh M. Osman & Claudiu T. Supuran
Pages: 430-434
Published online: 04 Aug 2014
AbstractforNew series of sulfonamides containing amino acid moiety act as effective and selective inhibitors of tumor-associated carbonic anhydrase XII | Full Text | References | PDF (303.6 KB)
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Research Article

Article
Synthesis and antioxidant activities of some new triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings
Emre Menteşe, Fatih Yılmaz, Nimet Baltaş, Olcay Bekircan & Bahittin Kahveci
Pages: 435-441
Published online: 08 Sep 2014
AbstractforSynthesis and antioxidant activities of some new triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings | Full Text | References | PDF (218.4 KB)
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Article
Purification of xanthine oxidase from bovine milk by affinity chromatography with a novel gel
Serap Beyaztaş & Oktay Arslan
Pages: 442-447
Published online: 04 Aug 2014
AbstractforPurification of xanthine oxidase from bovine milk by affinity chromatography with a novel gel | Full Text | References | PDF (578.1 KB)
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Article
The impact of testosterone, tibolone and black cohosh on purified mammary and placental 17β-hydroxysteroid dehydrogenase type 1
Petra Stute, Kathrin Kalkhake, Ludwig Kiesel & Martin Götte
Pages: 448-457
Published online: 11 Aug 2014
AbstractforThe impact of testosterone, tibolone and black cohosh on purified mammary and placental 17β-hydroxysteroid dehydrogenase type 1 | Full Text | References | PDF (792.8 KB)
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Article
Synthesis and antitumor activity evaluation of new 2-(4-aminophenyl)benzothiazole derivatives bearing different heterocyclic rings
Leyla Yurttaş, Funda Tay & Şeref Demirayak
Pages: 458-465
Published online: 08 Sep 2014
AbstractforSynthesis and antitumor activity evaluation of new 2-(4-aminophenyl)benzothiazole derivatives bearing different heterocyclic rings | Full Text | References | PDF (632 KB)
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Original Article

Article
Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors
Andrea Trabocchi, Nicolino Pala, Ilga Krimmelbein, Gloria Menchi, Antonio Guarna, Mario Sechi, Tobias Dreker, Andrea Scozzafava, Claudiu T. Supuran & Fabrizio Carta
Pages: 466-471
Published online: 08 Sep 2014
AbstractforPeptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors | Full Text | References | PDF (595.6 KB) | Supplemental
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Original Articles

Article
Ligand structures of synthetic deoxa-pyranosylamines with raucaffricine and strictosidine glucosidases provide structural insights into their binding and inhibitory behaviours
Liqun Xia, Haili Lin, Agata Staniek, Santosh Panjikar, Martin Ruppert, Petra Hilgers, Jörg Williardt, Chitra Rajendran, Meitian Wang, Heribert Warzecha, Volker Jäger & Joachim Stöckigt
Pages: 472-478
Published online: 20 Aug 2014
AbstractforLigand structures of synthetic deoxa-pyranosylamines with raucaffricine and strictosidine glucosidases provide structural insights into their binding and inhibitory behaviours | Full Text | References | PDF (1.6 MB) | Supplemental
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Original Article

Article
Inhibition profile of a series of phenolic acids on bovine lactoperoxidase enzyme
S. Beyza Ozturk Sarikaya, Melda Sisecioglu, Murat Cankaya, İlhami Gulcin & Hasan Ozdemir
Pages: 479-483
Published online: 08 Sep 2014
AbstractforInhibition profile of a series of phenolic acids on bovine lactoperoxidase enzyme | Full Text | References | PDF (274.3 KB)
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Article
Synthesis, characterization and biological evaluation of novel 4′-fluoro-2′-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents
Khaled R. A. Abdellatif, Heba A. H. Elshemy, Samir A. Salama & Hany A. Omar
Pages: 484-491
Published online: 08 Sep 2014
AbstractforSynthesis, characterization and biological evaluation of novel 4′-fluoro-2′-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents | Full Text | References | PDF (564.4 KB)
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Review Article

Quinoline and quinolones: promising scaffolds for future antimycobacterial agents
Sandeep Singh, Gurpuneet Kaur, Veenu Mangla & Manish K. Gupta
Pages: 492-504
Published online: 17 Jul 2014
AbstractforQuinoline and quinolones: promising scaffolds for future antimycobacterial agents | Full Text | References | PDF (2.2 MB)
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Drosophila melanogaster: a model organism for controlling Dipteran vectors and pests
Reza Zolfaghari Emameh, Leo Syrjänen, Harlan Barker, Claudiu T. Supuran & Seppo Parkkila
Pages: 505-513
Published online: 08 Sep 2014
AbstractforDrosophila melanogaster: a model organism for controlling Dipteran vectors and pests | Full Text | References | PDF (1.3 MB)
  • 2889 Views
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Short Communication

The glycoglycerolipid 1,2-dipalmitoyl-3-(N-palmitoyl-6′-amino-6′-deoxy-α-d-glucosyl)-sn-glycerol is no inhibitor of the human Myt1 kinase
Alexander Rohe, Christiane Göllner, Frank Erdmann, Wolfgang Sippl & Matthias Schmidt
Pages: 514-517
Published online: 18 Jun 2014
AbstractforThe glycoglycerolipid 1,2-dipalmitoyl-3-(N-palmitoyl-6′-amino-6′-deoxy-α-d-glucosyl)-sn-glycerol is no inhibitor of the human Myt1 kinase | Full Text | References | PDF (209.3 KB)
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