High Expression of Cathepsin E is Associated with the Severity of Airflow Limitation in Patients with COPD

Abstract

Background: It was reported that Cathepsin E (Cat E) plays a critical role in antigen processing and in the development of pulmonary emphysema. The aim of this study was to investigate the role of Cat E and airflow limitation in the pathogenesis of COPD. Methods: Sixty-five patients with COPD, 20 smoking control subjects without COPD and 15 non-smoking healthy control subjects were enrolled. Cat E and EIC (Elastase inhibitory capacity) expressions were measured by ELISA in sputum and serum samples and compared according to different subgroups. Results: Cat E concentrations were significantly higher in patients with COPD than smoking control and non-smoking control subjects (P < 0.01). The levels of CatE were inversely correlated with FEV₁% predicted in COPD patients (r = −0.95, P < 0.01). The levels of EIC were inversely positively correlated with FEV₁% predicted in COPD patients (r = 0.926, P < 0.01). Levels of Cat E were also inversely correlated with the levels of EIC (r = −0.922, P < 0.01). Conclusions: Cat E contributes to the severity of airflow limitation during progression of COPD.

Keywords:

• airflow limitation
• airway remodeling
• Cathepsin E
• COPD