High Expression of Cathepsin E is Associated with the Severity of Airflow Limitation in Patients with COPD

References

• Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380(9859):2163–2196.
   PubMed Web of Science ®Google Scholar
• Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD). 2014. Available from: http://www.goldcopd.org/uploads/users/files/ ( accessed 2 November 2014).
   Google Scholar
• World Health Organization, Reviewed October 2013: Chronic obstructive pulmonary disease (COPD). 2013. Available from: URL: http://www.who.int/mediacentre/factsheets/fs315/en/( accessed 2 November 2014).
   Google Scholar
• Jeffery PK. Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med 2001; 164:S28–S38.
   PubMedGoogle Scholar
• Zaidi N, Kalbacher H. Cathepsin E: A mini review. Biochem Biophys Res Commun 2008; 367(3):517–522.
   PubMed Web of Science ®Google Scholar
• Overall CM, Kleifeld O. Tumour microenvironment—­opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer 2006; 6(3):227–239.
   PubMed Web of Science ®Google Scholar
• Kawakubo T, Okamoto K, Iwata J. Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface. Cancer Res 2007; 67(22):10869–10878.
   PubMed Web of Science ®Google Scholar
• Tsukuba T, Okamoto K, Okamoto Y. Association of cathepsin E deficiency with development of atopic dermatitis. J Biochem 2003; 134(6):893–902.
   PubMed Web of Science ®Google Scholar
• Henningsson F, Yamamoto K, Saftig P. A role for cathepsin E in the processing of mast-cell carboxypeptidase A. J Cell Sci 2005; 118(Pt 9):2035–2042.
   PubMed Web of Science ®Google Scholar
• Tsukuba T, Yamamoto, S, Yanagawa, M, Yamamoto. Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors. J Biochem 2006; 140(1):57–66.
   PubMed Web of Science ®Google Scholar
• Sessa F, Bonato M, Frigerio B. Ductal cancers of the pancreas frequently express markers of gastrointestinal epithelial cells. Gastroenterology 1990; 98(6):1655–1665.
   PubMed Web of Science ®Google Scholar
• Tenti P, Romagnoli S, Silini E. Cervical adenocarcinomas express markers common to gastric, intestinal, and pancreatobiliary epithelial cells. Pathol Res Pract 1994; 190(4):342–349.
   PubMed Web of Science ®Google Scholar
• Ullmann R, Morbini P, Halbwedl I. Protein expression profiles in adenocarcinomas and squamous cell carcinomas of the lung generated using tissue microarrays. J Pathol 2004; 203(3):798–807.
   PubMed Web of Science ®Google Scholar
• Yasukochi A, Kawakubo T, Nakamura S. Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis. Biol Chem 2010; 391(8):947–958.
   PubMed Web of Science ®Google Scholar
• Uno K, Azuma T, Nakajima M. Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma. J Gastroenterol Hepatol 2000; 15(11):1333–1338.
   PubMed Web of Science ®Google Scholar
• Kawakubo T, Okamoto K, Iwata J. Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface. Cancer Res 2007; 67(22):10869–10878.
   PubMed Web of Science ®Google Scholar
• Zhang X, Shan P, Homer R, et al. Cathepsin E promotes pulmonary emphysema via mitochondrial fission. Am J Pathol 2014; 184(10):2730–2741.
   PubMed Web of Science ®Google Scholar
• Vestbo J, Hurd SS, Agustí AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013; 187(4):347–365.
   PubMed Web of Science ®Google Scholar
• Pizzichini E, Pizzichini MM, Leigh R, et al. Safety of sputum induction. Eur Respir J Suppl 2002; 37:9s–18s.
   PubMedGoogle Scholar
• Demedts IK, Morel-Montero A, Lebecque S, et al. Elevated MMP-12 protein levels in induced sputum from patients with COPD. Thorax 2006; 61(3):196–201.
   PubMed Web of Science ®Google Scholar
• Bieth J, Wermuth CG. The action of elastase on p-nitroanilide substrates. Biochem Biophys Res Commun 1973; 53(2):383–390.
   PubMed Web of Science ®Google Scholar
• Ying QL, Simon SR. DNA from bronchial secretions modulates elastase inhibition by alpha(1)-proteinase inhibitor and oxidized secretory leukoprotease inhibitor. Am J Respir Cell Mol Biol 2000; 23(4):506–513.
   PubMed Web of Science ®Google Scholar
• Borzone G, Liberona L, Olmos P. Rat and hamster species differences in susceptibility to elastase-induced pulmonary emphysema relate to differences in elastase inhibitory capacity. Am J Physiol Regul Integr Comp Physiol 2007; 293(3):R1342–1349.
   PubMed Web of Science ®Google Scholar
• Society AT. Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med 1995; 152(3):1107–1136.
   Google Scholar
• Ritz T, Dahme B, Dubois AB. Guidelines for mechanical lung function measurements in psychophysiology. Psychophysiology 2002; 39(5):546–567.
   PubMed Web of Science ®Google Scholar
• Cheng DT, Kim DK, Cockayne DA, et al. Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 188(8):948–957.
   PubMed Web of Science ®Google Scholar
• Mori K, Shirai T, Mikamo M, et al. Respiratory mechanics measured by forced oscillation technique in combined pulmonary fibrosis and emphysema. Respir Physiol Neurobiol 2013; 185(2):235–240.
   PubMed Web of Science ®Google Scholar
• Goddard PR, Nicholson EM, Laszlo G. Computed tomography in pulmonary emphysema. Clin Radiol 1982; 33(4):379–387.
   PubMed Web of Science ®Google Scholar
• Bosi F, Silini E, Luisetti M. Aspartic proteinases in normal lung and interstitial pulmonary diseases. Am J Respir Cell Mol Biol 1993; 8(6):626–632.
   PubMed Web of Science ®Google Scholar
• Nishioku T, Hashimoto K, Yamashita K. Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia. J Biol Chem 2002; 277(7):4816–4822.
   PubMed Web of Science ®Google Scholar
• Tsukuba T, Okamoto K, Yasuda Y. New functional aspects of cathepsin D and cathepsin E. Mol Cells 2000; 10(6):601–611.
   PubMed Web of Science ®Google Scholar
• Senior RM, Connolly NL, Cury JD. Elastin degradation by human alveolar macrophages. A prominent role of metalloproteinase activity. Am Rev Respir Dis 1989; 139(5):1251–1256.
   PubMed Web of Science ®Google Scholar
• De Water R, Willems LN, Van Muijen GN. Ultrastructural localization of bronchial antileukoprotease in central and peripheral human airways by a gold-labeling technique using monoclonal antibodies. Am Rev Respir Dis 1986; 133(5):882–890.
   PubMed Web of Science ®Google Scholar
• Yokohori N, Aoshiba K, Nagai A. Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema. Chest 2004; 125(2):626–632.
   PubMed Web of Science ®Google Scholar
• McElvaney NG, Birrer P, Chang-Stroman LM, Crystal RG. Neutrophil elastase and the fragile lung: the pathogenesis and therapeutic strategies relating to lung derangement in the common hereditary lung disorders. In: Grassi C, Travis J, Casali L, Luisetti M, eds. Biochemistry of Pulmonary Emphysema. 1st ed. London, UK: Springer; 1992:169–187.
   Google Scholar
• Fujita J, Nelson NL, Daughton DM, et al. Evaluation of elastase and antielastase balance in patients with chronic bronchitis and pulmonary emphysema. Am Rev Respir 1990; 142(1):57–62.
   PubMed Web of Science ®Google Scholar
• Abd-Elgaliel WR, Tung CH. Selective detection of Cathepsin E proteolytic activity. Biochim Biophys Acta 2010; 1800(9):1002–1008.
   PubMed Web of Science ®Google Scholar
• Athauda SB, Takahashi T, Inoue H, et al. Proteolytic activity and cleavage specificity of Cathepsin E at the physiological pH as examined towards the B chain of oxidized insulin. FEBS Lett 1991; 292(1–2):53–56.
   PubMed Web of Science ®Google Scholar
• Liao SX, Ding T, Rao XM, et al. Cigarette smoke affects dendritic cell maturation in the small airways of patients with chronic obstructive pulmonary disease. Mol Med Rep 2015; 11(1):219–225.
   PubMed Web of Science ®Google Scholar
• Wielgat P, Mroz RM, Stasiak-Barmuta A, et al. Inhaled corticosteroids increase Siglec-5/14 expression in sputum cells of COPD patients. Adv Exp Med Biol 2015; 839:1–5.
   PubMed Web of Science ®Google Scholar
• Snoeck-Stroband JB, Postma DS, Lapperre TS. Airway inflammation contributes to health status in COPD: a cross-sectional study. Respir Res 2006; 7:140.
   PubMed Web of Science ®Google Scholar
• Lapperre TS, Willems LN, Timens W. Small airways dysfunction and neutrophilic inflammation in bronchial biopsies and BAL in COPD. Chest 2007; 131(1):53–59.
   PubMed Web of Science ®Google Scholar
• Vlahos R, Bozinovski S. Role of alveolar macrophages in chronic obstructive pulmonary disease. Front Immunol 2014; 5:435.
   PubMed Web of Science ®Google Scholar