![Sample our Environment & Agriculture journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5934/TOC-Subject-Sample-2021-Environment-Agriculture.jpg"})
Abstract
Aim: Vascular leakage following cardiopulmonary bypass contributes to morbidity. Angiopoietin-1 and -2 are biomarkers of endothelial dysfunction. Our aim was to characterize Ang-1 and -2 association with clinical characteristics and outcomes. Methods: Observational cohort study measuring Ang-1/-2 with a panel of cytokines in adults undergoing cardiopulmonary bypass. Results: Ang-2 levels increased immediately postop whereas Ang-1 levels decreased over time. No significant correlation was found with other inflammatory mediators. High correlation was found between the hospital length of stay and Ang-2 increase at 24 h (rho = 0.590; p < 0.0001). The predictors of Ang-2 increase were female gender, cross clamp time, transfusion of blood and absence of angiotensin-converting enzyme inhibitor as a pre-op medication. Conclusion: Angiopoietins can detect vascular leakage early and could impact patient's management to decrease length of stay after cardiac surgery.
Lay abstract Following cardiac surgery, patients develop swelling due to fluid leaking from their vessels into their tissues. We know that more swelling contributes to a longer stay in the hospital. The present study links a marker of vessel instability, namely angiopoietin (which we think could contribute to detect leakage), with patient's hospital length of stay. We also report patient's characteristics that are related to the release of angiopoietin. The measure of this marker after cardiac surgery could provide physicians with an alert signal and trigger treatments to minimize swelling that could impact on hospital stay.
Authors’ contributions
E Charbonney and E Wilcox contributed equally to this work. E Charbonney participated to the conception, the design of the study, the collection of data, the analysis of the results and the draft of the manuscript. E Wilcox participated to the conception, the design of the study, the collection of data, the analysis of the results and the draft of the manuscript. Y Shan conducted the blood samples analysis and help with the interpretation of results and the drafting of the manuscript. PP d'Empaire contributed to the collection of the data and the draft of the manuscript. A Duggal contributed to the collection of data and the draft of the manuscript. GD Rubenfeld participated to the conception of the study, its design and its coordination and helped to draft the manuscript. WC Liles participated to the conception, the design of the study, the analysis and interpretation of the results, as well as drafting the manuscript. CD Santos conceived the study, participated to the design of the study, the analysis and interpretation of the results, as well as drafting the manuscript.
Acknowledgements
Partial results of this work have been presented on 30 September 2014, at the 27th ESICM meeting in Barcelona (Spain).
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved. For investigations involving human subjects, informed consent has been obtained from the participants involved and an explanation of how this was obtained is included in the manuscript.