Systemic Angiopoietin-1/2 Dysregulation Following Cardiopulmonary Bypass in Adults

References

• Westaby S. Organ dysfunction after cardiopulmonary bypass. A systemic inflammatory reaction initiated by the extracorporeal circuit. Intensive Care Med. 13(2), 89–95 (1987).
   PubMed Web of Science ®Google Scholar
• Biglioli P, Cannata A, Alamanni F et al. Biological effects of off-pump vs. on-pump coronary artery surgery: focus on inflammation, hemostasis and oxidative stress. Eur. J. Cardiothorac. Surg. 24(2), 260–269 (2003).
   PubMed Web of Science ®Google Scholar
• Toraman F, Evrenkaya S, Yuce M et al. Highly positive intraoperative fluid balance during cardiac surgery is associated with adverse outcome. Perfusion 19(2), 85–91 (2004).
   PubMed Web of Science ®Google Scholar
• Wheeler DS, Dent CL, Manning PB, Nelson DP. Factors prolonging length of stay in the cardiac intensive care unit following the arterial switch operation. Cardiol. Young 18(1), 41–50 (2008).
   PubMed Web of Science ®Google Scholar
• Seghaye MC, Duchateau J, Grabitz RG et al. Complement activation during cardiopulmonary bypass in infants and children. Relation to postoperative multiple system organ failure. J. Thorac. Cardiovasc. Surg. 106(6), 978–987 (1993).
   PubMed Web of Science ®Google Scholar
• Casey LC. Role of cytokines in the pathogenesis of cardiopulmonary-induced multisystem organ failure. Ann. Thorac. Surg. 56(Suppl. 5), S92–S96 (1993).
   PubMed Web of Science ®Google Scholar
• Rossaint J, Berger C, Van Aken H et al. Cardiopulmonary bypass during cardiac surgery modulates systemic inflammation by affecting different steps of the leukocyte recruitment cascade. PLoS ONE 7(9), e45738 (2012).
   PubMed Web of Science ®Google Scholar
• Boyle EMJ, Pohlman TH, Johnson MC, Verrier ED. Endothelial cell injury in cardiovascular surgery: the systemic inflammatory response. Ann. Thorac. Surg. 63(1), 277–284 (1997).
   PubMedGoogle Scholar
• Wan S, LeClerc JL, Vincent JL. Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest 112(3), 676–692 (1997).
   PubMed Web of Science ®Google Scholar
• Fiedler U, Reiss Y, Scharpfenecker M et al. Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat. Med. 12(2), 235–239 (2006).
   PubMed Web of Science ®Google Scholar
• Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 101(10), 3765–3777 (2003).
   PubMed Web of Science ®Google Scholar
• Fiedler U, Augustin HG. Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol. 27(12), 552–558 (2006).
   PubMed Web of Science ®Google Scholar
• Ricciuto DR, Santos Dos CC, Hawkes M et al. Angiopoietin-1 and Angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis. Crit. Care Med. 39(4), 702–710 (2011).
   PubMed Web of Science ®Google Scholar
• Parikh SM, Mammoto T, Schultz A et al. Excess circulating Angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med. 3(3), e46 (2006).
   PubMed Web of Science ®Google Scholar
• Orfanos SE, Kotanidou A, Glynos C et al. Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators. Crit. Care Med. 35(1), 199–206 (2007).
   PubMed Web of Science ®Google Scholar
• Hilbert T, Duerr GD, Hamiko M et al. Endothelial permeability following coronary artery bypass grafting: an observational study on the possible role of angiopoietin imbalance. Crit. Care 20, 51 (2016).
   PubMed Web of Science ®Google Scholar
• Uchida T, Ito H, Yamamoto H et al. Elevated levels of Angiopoietin-2 as a biomarker for respiratory failure after cardiac surgery. J. Cardiothorac. Vasc. Anesth. 28(5), 1293–1301 (2014).
   PubMed Web of Science ®Google Scholar
• Clajus C, Lukasz A, David S et al. Angiopoietin-2 is a potential mediator of endothelial barrier dysfunction following cardiopulmonary bypass. Cytokine 60(2), 352–359 (2012).
   PubMed Web of Science ®Google Scholar
• Wilcox ME, Charbonney E, d'Empaire PP et al. Oral neutrophils are an independent marker of the systemic inflammatory response after cardiac bypass. J. Inflamm. (Lond). 11(1), 32 (2014).
   PubMedGoogle Scholar
• Peterson ED, Coombs LP, Ferguson TB et al. Hospital variability in length of stay after coronary artery bypass surgery: results from the Society of Thoracic Surgeon's National Cardiac Database. Ann. Thorac. Surg. 74(2), 464–473 (2002).
   PubMed Web of Science ®Google Scholar
• Kim I, Kim JH, Ryu YS, Liu M, Koh GY. Tumor necrosis factor-alpha upregulates Angiopoietin-2 in human umbilical vein endothelial cells. Biochem. Biophysi. Res. Commun. 269(2), 361–365 (2000).
   PubMed Web of Science ®Google Scholar
• Augustin HG, Koh GY, Thurston G, Alitalo K. Control of vascular morphogenesis and homeostasis through the Angiopoietin-Tie system. Nat. Rev. Mol. Cell. Biol. 10(3), 165–177 (2009).
   PubMed Web of Science ®Google Scholar
• Koning NJ, Overmars MAH, van den Brom CE et al. Endothelial hyperpermeability after cardiac surgery with cardiopulmonary bypass as assessed using an in vitro bioassay for endothelial barrier function. Br. J. Anaesth. 116(2), 223–232 (2016).
   PubMed Web of Science ®Google Scholar
• Giuliano JS Jr, Lahni PM, Bigham MT et al. Plasma Angiopoietin-2 levels increase in children following cardiopulmonary bypass. Intensive Care Med. 34(10), 1851–1857 (2008).
   PubMed Web of Science ®Google Scholar
• Jongman RM, van Klarenbosch J, Molema G, Zijlstra JG, de Vries AJ, van Meurs M. Angiopoietin/Tie2 dysbalance is associated with acute kidney injury after cardiac surgery assisted by cardiopulmonary bypass. PLoS ONE 10(8), e0136205 (2015).
   PubMed Web of Science ®Google Scholar
• Lorbeer R, Baumeister SE, Dorr M et al. Angiopoietin-2, its soluble receptor Tie-2 and subclinical cardiovascular disease in a population-based sample. Heart 101(3), 178–184 (2015).
   PubMed Web of Science ®Google Scholar
• Nadar SK, Blann A, Beevers DG, Lip GYH. Abnormal Angiopoietins 1&2, Angiopoietin receptor Tie-2 and vascular endothelial growth factor levels in hypertension: relationship to target organ damage [a sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)]. J. Intern. Med. 258(4), 336–343 (2005).
   PubMed Web of Science ®Google Scholar
• Cui X, Chopp M, Zacharek A, Ye X, Roberts C, Chen J. Angiopoietin/Tie2 pathway mediates Type 2 diabetes induced vascular damage after cerebral stroke. Neurobiol. Dis. 43(1), 285–292 (2011).
   PubMed Web of Science ®Google Scholar
• Jongman RM, Zijlstra JG, Kok WF et al. Off-pump cabg surgery reduces systemic inflammation compared with on-pump surgery but does not change systemic endothelial responses. Shock 42(2), 121–128 (2014).
   PubMed Web of Science ®Google Scholar
• Mehta RL, Bouchard J. Controversies in acute kidney injury: effects of fluid overload on outcome. Contrib. Nephrol. 174, 200–211 (2011).
   PubMed Web of Science ®Google Scholar
• Hassinger AB, Wald EL, Goodman DM. Early postoperative fluid overload precedes acute kidney injury and is associated with higher morbidity in pediatric cardiac surgery patients. Pediatr. Crit. Care Med. 15(2), 131–138 (2014).
   PubMed Web of Science ®Google Scholar
• Hilbert T, Poth J, Frede S et al. Anti-atherogenic effects of statins: impact on Angiopoietin-2 release from endothelial cells. Biochem. Pharmacol. 86(10), 1452–1460 (2013).
   PubMed Web of Science ®Google Scholar
• Murphy GJ, Pike K, Rogers CA et al. Liberal or restrictive transfusion after cardiac surgery. N. Engl. J. Med. 372(11), 997–1008 (2015).
   PubMed Web of Science ®Google Scholar