New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity

Abstract

Plasmacytoid dendritic cells (pDCs) are not only potent inflammatory cytokine producers but also function as antigen-presenting cells (APCs). We have shown that vaccination using CpG-B activated tumor antigen (Ag) presenting pDCs induce Th17 cells that promote intratumoral immune cell recruitment, including antitumor cytotoxic T lymphocytes CTLs. Therefore, strategies targeting both innate and adaptive pDC functions may improve antitumor T-cell immunity.

Keywords:

• antigen presentation
• anti-tumor immunity
• plasmacytoid dendritic cells
• Th17

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.