Ceramide stress in survival versus lethal autophagy paradox

Abstract

In a recent study, characterization of novel mechanisms that regulate lethal autophagy revealed that C₁₈-ceramide stress mediates LC3B-II-ceramide binding on mitochondrial membranes to target autophagosomes for mitophagy induction and tumor suppression.

Keywords: :

• sphingolipid
• ceramide
• mitophagy
• mitochondrial fission
• lipid-protein interaction
• ceramide synthase

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Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.