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Review

Extrinsic aging

UV-mediated skin carcinogenesis

, , , &
Pages 285-297 | Received 12 Aug 2012, Accepted 11 Oct 2012, Published online: 01 Jul 2012
 

Abstract

Age-associated skin lesions linked to UV radiation (UVR) include actinic keratosis, non-melanoma skin cancer—such as basal cell carcinoma and squamous cell carcinoma—lentigo senilis and lentigo maligna. Their incidence is increasing worldwide, mainly due to exaggerated UV exposure and to an aging population. Early diagnosis and therapy of pre-malignant cutaneous lesions is crucial for the secondary prophylaxis of invasive and highly aggressive skin cancers. Combined efforts to increase public awareness, patient education about self-examination, prophylactic modalities, such as consistent and sufficient UV protection, and rigorous follow-up of high-risk groups are of highest importance.

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.