Antagonizing the innate pattern recognition receptor CD204 to improve dendritic cell-targeted cancer immunotherapy

Abstract

Extensive studies have established a role of scavenger receptor CD204 in pattern recognition and ligand uptake. Strikingly, we recently revealed a previously unrecognized feature of CD204 action in attenuating T-cell activation and antitumor immunity. Blocking its activity in dendritic cells represents a promising approach to the improvement of cancer immunotherapy.

Keywords: :

• innate immune receptor
• dendritic cells
• CD204
• vaccine
• T-cell response
• tumor immunity