OncoImmunology, Volume 1, Issue 5 (2012)

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OncoImmunology, Volume 1, Issue 5 (2012)

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Editor's Corner

Editorial
Can the exome and the immunome converge on the design of efficient cancer vaccines?
Guido Kroemer & Laurence Zitvogel
Pages: 579-580
Published online: 24 Aug 2012
AbstractforCan the exome and the immunome converge on the design of efficient cancer vaccines? | Full Text | References | PDF (96.6 KB)
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Research Paper

Article
Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c+/CD8α+ dendritic cells
Masahiro Azuma, Takashi Ebihara, Hiroyuki Oshiumi, Misako Matsumoto & Tsukasa Seya
Pages: 581-592
Published online: 24 Aug 2012
AbstractforCross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c+/CD8α+ dendritic cells | Full Text | References | PDF (1.6 MB) | Supplemental
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Article
Sequential metastases of colorectal cancer
Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments
Sophia Keim, Inka Zoernig, Anna Spille, Bernd Lahrmann, Karsten Brand, Esther Herpel, Niels Grabe, Dirk Jäger & Niels Halama
Pages: 593-599
Published online: 24 Aug 2012
AbstractforSequential metastases of colorectal cancer | Full Text | References | PDF (2.4 MB) | Supplemental
  • 889 Views
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Article
The protooncogene Vav1 regulates murine leukemia virus-induced T-cell leukemogenesis
Sandra Kaminski, Oumeya Adjali, Chantal Jacquet, Johan Garaude, Anne Keriel, Adeline Lassaux, Robert Hipskind, Marc Sitbon, Naomi Taylor & Martin Villalba
Pages: 600-608
Published online: 24 Aug 2012
AbstractforThe protooncogene Vav1 regulates murine leukemia virus-induced T-cell leukemogenesis | Full Text | References | PDF (1.1 MB)
  • 486 Views
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Open Access
Article
Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma
Anna Hooijkaas, Jules Gadiot, Michelle Morrow, Ross Stewart, Ton Schumacher & Christian U. Blank
Pages: 609-617
Published online: 24 Aug 2012
AbstractforSelective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma | Full Text | References | PDF (2.5 MB) | Supplemental
  • 1679 Views
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Article
Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia
Niklas Feldhahn, Anna Arutyunyan, Sonia Stoddart, Bin Zhang, Sabine Schmidhuber, Sun-Ju Yi, Yong-mi Kim, John Groffen & Nora Heisterkamp
Pages: 618-629
Published online: 24 Aug 2012
AbstractforEnvironment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia | Full Text | References | PDF (4.7 MB) | Supplemental
  • 1008 Views
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Open Access
Article
Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease
Satoko Fujii, Hiromichi Hara, Jun Araya, Naoki Takasaka, Jun Kojima, Saburo Ito, Shunsuke Minagawa, Yoko Yumino, Takeo Ishikawa, Takanori Numata, Makoto Kawaishi, Jun Hirano, Makoto Odaka, Toshiaki Morikawa, Stephen Nishimura, Katsutoshi Nakayama & Kazuyoshi Kuwano
Pages: 630-641
Published online: 24 Aug 2012
AbstractforInsufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease | Full Text | References | PDF (2.4 MB)
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Open Access
Article
Tumor antigen specific iTreg accumulate in the tumor microenvironment and suppress therapeutic vaccination
Taylor H. Schreiber, Dietlinde Wolf, Maria Bodero & Eckhard Podack
Pages: 642-648
Published online: 24 Aug 2012
AbstractforTumor antigen specific iTreg accumulate in the tumor microenvironment and suppress therapeutic vaccination | Full Text | References | PDF (506 KB) | Supplemental
  • 1016 Views
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Open Access
Article
Tumor-mediated inhibition of human dendritic cell differentiation and function is consistently counteracted by combined p38 MAPK and STAT3 inhibition
Dinja Oosterhoff, Sinéad Lougheed, Rieneke van de Ven, Jelle Lindenberg, Hester van Cruijsen, Lotte Hiddingh, Jan Kroon, Alfons J.M. van den Eertwegh, Basav Hangalapura, Rik J. Scheper & Tanja D. de Gruijl
Pages: 649-658
Published online: 24 Aug 2012
AbstractforTumor-mediated inhibition of human dendritic cell differentiation and function is consistently counteracted by combined p38 MAPK and STAT3 inhibition | Full Text | References | PDF (974.8 KB)
  • 1171 Views
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Article
CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4+ T effector cells in patients with head and neck squamous cell carcinoma
Magis Mandapathil, Miroslaw Szczepanski, Malgorzata Harasymczuk, Jin Ren, Dongmei Cheng, Edwin K. Jackson, Elieser Gorelik, Jonas Johnson, Stephan Lang & Theresa L Whiteside
Pages: 659-669
Published online: 24 Aug 2012
AbstractforCD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4+ T effector cells in patients with head and neck squamous cell carcinoma | Full Text | References | PDF (2.1 MB)
  • 1678 Views
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Open Access
Article
Widespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001
Else-Marit Inderberg-Suso, Sissel Trachsel, Kari Lislerud, Anne-Marie Rasmussen & Gustav Gaudernack
Pages: 670-686
Published online: 24 Aug 2012
AbstractforWidespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001 | Full Text | References | PDF (3.9 MB) | Supplemental
  • 1439 Views
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Brief Report

Brief Report
TLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA let-7b
Dapeng Li, Haibo Jia, Huafeng Zhang, Meng Lv, Jing Liu, Yi Zhang, Tao Huang & Bo Huang
Pages: 687-693
Published online: 24 Aug 2012
AbstractforTLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA let-7b | Full Text | References | PDF (1.2 MB)
  • 1329 Views
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Open Access
Brief Report
Detection of functional antigen-specific T cells from urine of non-muscle invasive bladder cancer patients
Claire Pieraerts, Virginie Martin, Patrice Jichlinski, Denise Nardelli-Haefliger & Laurent Derre
Pages: 694-698
Published online: 24 Aug 2012
AbstractforDetection of functional antigen-specific T cells from urine of non-muscle invasive bladder cancer patients | Full Text | References | PDF (401.1 KB)
  • 894 Views
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Open Access

Review

Review Article
Trial Watch
Experimental Toll-like receptor agonists for cancer therapy
Lorenzo Galluzzi, Erika Vacchelli, Alexander Eggermont, Wolf Hervé Fridman, Jérôme Galon, Catherine Sautès-Fridman, Eric Tartour, Laurence Zitvogel & Guido Kroemer
Pages: 699-739
Published online: 01 Aug 2012
AbstractforTrial Watch | Full Text | References | PDF (645.3 KB)
  • 2954 Views
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Open Access
Review Article
The split nature of tumor-infiltrating leukocytes
Implications for cancer surveillance and immunotherapy
Telma Lança & Bruno Silva-Santos
Pages: 717-725
Published online: 24 Aug 2012
AbstractforThe split nature of tumor-infiltrating leukocytes | Full Text | References | PDF (958.7 KB)
  • 1784 Views
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Review Article
Plasmacytoid dendritic cells and their therapeutic activity in cancer
Aldo Pinto, Alessia Rega, Timothy R Crother & Rosalinda Sorrentino
Pages: 726-734
Published online: 24 Aug 2012
AbstractforPlasmacytoid dendritic cells and their therapeutic activity in cancer | Full Text | References | PDF (1.1 MB)
  • 844 Views
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Open Access

Point of View

PD-1 and BTLA and CD8+ T-cell “exhaustion” in cancer
“Exercising” an alternative viewpoint
Cara Haymaker, Richard C. Wu, Chantale Bernatchez & Laszlo G. Radvanyi
Pages: 735-738
Published online: 24 Aug 2012
AbstractforPD-1 and BTLA and CD8+ T-cell “exhaustion” in cancer | Full Text | References | PDF (722.9 KB)
  • 2099 Views
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Author's View

Cytomegalovirus infection in brain tumors
A potential new target for therapy?
Cecilia Söderberg-Nauclér & John Inge Johnsen
Pages: 739-740
Published online: 24 Aug 2012
AbstractforCytomegalovirus infection in brain tumors | Full Text | References | PDF (418.7 KB)
  • 655 Views
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Open Access
Combining forces to hit cancer stem cells
TRAIL-lymphocytes and EpCAMxCD3 bispecific antibody show efficacy against pancreatic cancer
Ingrid Herr, Ariane Groth, Alexei V. Salnikov, Markus W. Buchler & Gerhard Moldenhauer
Pages: 741-743
Published online: 24 Aug 2012
AbstractforCombining forces to hit cancer stem cells | Full Text | References | PDF (486.5 KB)
  • 541 Views
  • 1 CrossRef citations
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Open Access
Insight into the dynamics, localization and magnitude of antigen-specific immune responses by [18F]FLT PET imaging
Erik H.J.G. Aarntzen, Mangala Srinivas, Cornelius J.A. Punt, Carl G. Figdor, Wim J.G. Oyen & I. Jolanda M. de Vries
Pages: 744-745
Published online: 24 Aug 2012
AbstractforInsight into the dynamics, localization and magnitude of antigen-specific immune responses by [18F]FLT PET imaging | Full Text | References | PDF (587.5 KB)
  • 403 Views
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Open Access
miRNA-mediated GALNT modulation of invasion and immune suppression
A sweet deal for metastatic cells
Avital Gaziel-Sovran & Eva Hernando
Pages: 746-748
Published online: 24 Aug 2012
AbstractformiRNA-mediated GALNT modulation of invasion and immune suppression | Full Text | References | PDF (793.2 KB)
  • 630 Views
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Open Access
Bcl-2
Live and let die
Eva Maria Putz, Christian Schuster & Veronika Sexl
Pages: 749-750
Published online: 24 Aug 2012
AbstractforBcl-2 | Full Text | References | PDF (500.6 KB)
  • 428 Views
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Open Access
Tumor conditioned media from colorectal cancer patients inhibits dendritic cell maturation
Adriana J. Michielsen, Jacintha N. O’Sullivan & Elizabeth J. Ryan
Pages: 751-753
Published online: 24 Aug 2012
AbstractforTumor conditioned media from colorectal cancer patients inhibits dendritic cell maturation | Full Text | References | PDF (433.2 KB)
  • 1115 Views
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Open Access
Mast cells in pancreatic ductal adenocarcinoma
David Z. Chang
Pages: 754-755
Published online: 24 Aug 2012
AbstractforMast cells in pancreatic ductal adenocarcinoma | Full Text | References | PDF (461.9 KB)
  • 471 Views
  • 8 CrossRef citations
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Open Access
DKK1 as a novel target for myeloma immunotherapy
Jianfei Qian & Qing Yi
Pages: 756-758
Published online: 24 Aug 2012
AbstractforDKK1 as a novel target for myeloma immunotherapy | Full Text | References | PDF (393 KB)
  • 671 Views
  • 9 CrossRef citations
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Open Access
Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment
Christine Ménétrier-Caux, Julien Faget, Cathy Biota, Michael Gobert, Jean-Yves Blay & Christophe Caux
Pages: 759-761
Published online: 24 Aug 2012
AbstractforInnate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment | Full Text | References | PDF (745 KB)
  • 680 Views
  • 20 CrossRef citations
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Open Access
Key role of the positive feedback between PGE2 and COX2 in the biology of myeloid-derived suppressor cells
Nataša Obermajer & Pawel Kalinski
Pages: 762-764
Published online: 24 Aug 2012
AbstractforKey role of the positive feedback between PGE2 and COX2 in the biology of myeloid-derived suppressor cells | Full Text | References | PDF (205.7 KB)
  • 1072 Views
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Open Access
New strategies for melanoma immunotherapy
How to overcome immunosuppression in the tumor microenvironment
Viktor Umansky
Pages: 765-767
Published online: 24 Aug 2012
AbstractforNew strategies for melanoma immunotherapy | Full Text | References | PDF (500.2 KB)
  • 480 Views
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Open Access
Targeting the tumor mutanome for personalized vaccination therapy
Sebastian Kreiter, John C. Castle, Özlem Türeci & Ugur Sahin
Pages: 768-769
Published online: 24 Aug 2012
AbstractforTargeting the tumor mutanome for personalized vaccination therapy | Full Text | References | PDF (449.1 KB)
  • 1664 Views
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Antagonizing the innate pattern recognition receptor CD204 to improve dendritic cell-targeted cancer immunotherapy
Xiaofei Yu & Xiang-Yang Wang
Pages: 770-772
Published online: 24 Aug 2012
AbstractforAntagonizing the innate pattern recognition receptor CD204 to improve dendritic cell-targeted cancer immunotherapy | Full Text | References | PDF (565.9 KB)
  • 625 Views
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Open Access
Combining targeted therapy with immunotherapy (interferon-α)
Rational, efficacy in gastrointestinal stromal tumor model and implications in other malignancies
Lei L. Chen, Launce Gouw, Mahyar Sabripour, Wen-Jen Hwu & Robert S. Benjamin
Pages: 773-776
Published online: 24 Aug 2012
AbstractforCombining targeted therapy with immunotherapy (interferon-α) | Full Text | References | PDF (1.5 MB)
  • 606 Views
  • 9 CrossRef citations
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Open Access
Development of a novel universal immune receptor for antigen targeting
To Infinity and beyond
Katarzyna Urbanska & Daniel J. Powell
Pages: 777-779
Published online: 24 Aug 2012
AbstractforDevelopment of a novel universal immune receptor for antigen targeting | Full Text | References | PDF (770.8 KB)
  • 816 Views
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Effect of CpG ODN on monocytic myeloid derived suppressor cells
Hidekazu Shirota & Dennis M. Klinman
Pages: 780-782
Published online: 24 Aug 2012
AbstractforEffect of CpG ODN on monocytic myeloid derived suppressor cells | Full Text | References | PDF (680.1 KB)
  • 737 Views
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IL-17A is a central regulator of lung tumor growth
Sarah Reppert, Sonja Koch & Susetta Finotto
Pages: 783-785
Published online: 24 Aug 2012
AbstractforIL-17A is a central regulator of lung tumor growth | Full Text | References | PDF (456.5 KB)
  • 562 Views
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Open Access
The emergence of phox-ER stress induced immunogenic apoptosis
Abhishek D. Garg, Dmitri V. Krysko, Peter Vandenabeele & Patrizia Agostinis
Pages: 786-788
Published online: 24 Aug 2012
AbstractforThe emergence of phox-ER stress induced immunogenic apoptosis | Full Text | References | PDF (1.4 MB)
  • 1110 Views
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Tumor high endothelial venules (HEVs) predict lymphocyte infiltration and favorable prognosis in breast cancer
Ludovic Martinet, Ignacio Garrido & Jean-Philippe Girard
Pages: 789-790
Published online: 24 Aug 2012
AbstractforTumor high endothelial venules (HEVs) predict lymphocyte infiltration and favorable prognosis in breast cancer | Full Text | References | PDF (560.8 KB)
  • 861 Views
  • 33 CrossRef citations
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TG4010
A therapeutic vaccine against MUC1 expressing tumors
Jean-Marc Limacher & Elisabeth Quoix
Pages: 791-792
Published online: 24 Aug 2012
AbstractforTG4010 | Full Text | References | PDF (275.1 KB)
  • 865 Views
  • 28 CrossRef citations
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