Survivin-3B promotes chemoresistance and immune escape by inhibiting caspase-8 and -6 in cancer cells

Abstract

Survivin-3B (S-3B), an alternative splice isoform of survivin, plays a key role in tumorigenesis. S-3B promotes the escape of malignant cells from immune recognition by blocking the cytotoxicity of natural killer (NK) cells. Such an effect reflects the ability of S-3B to interfere with the assembly of the so-called “death-inducing signaling complex” upon the interaction of FAS with its ligand (FASL). S-3B also inhibits the activation of caspase-6, thus increasing the resistance of neoplastic cells to granzyme B and various chemotherapeutics.

Keywords: :

• caspase-6
• caspase-8
• survivin-3B
• tumorigenesis
• tumor escape
• treatment response

Citation: Végran F, Boidot R. Survivin-3B promotes chemoresistance and immune escape by inhibiting caspase-8 and -6 in cancer cells OncoImmunology 2013; 2:e26328; 10.4161/onci.26328

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.