hTERT deficiency in naïve T cells affects lymphocyte homeostasis in myelodysplastic syndrome patients

Abstract

Myelodysplastic syndromes (MDSs) are hematopoietic stem cell disorders with a high potential to develop into acute myeloid leukemia (AML). We have recently demonstrated that naïve T cells, but not memory T cells, from MDS patients exhibit a pronounced deficiency in the mRNA coding for the catalytic subunit of telomerase (hTERT). We discuss the importance of this finding for lymphocytic homeostasis in MDS patients.

Keywords: :

• bone marrow failure
• myelodysplastic syndrome
• telomere
• T lymphocyte

Citation: Yang L, Eksioglu E, Wei S. hTERT deficiency in naïve T cells affects lymphocyte homeostasis in myelodysplastic syndrome patients. OncoImmunology 2013; 2:e26329; 10.4161/onci.26329

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed