REG3β contributes to the immunosuppressive microenvironment of pancreatic cancer

Abstract

The levels of regenerating islet-derived 3β (REG3β) in the serum and pancreatic juice of patients affected by pancreatic ductal adenocarcinomas are increased. However, whether such an elevation is relevant to oncogenesis and tumor progression has not yet been carefully examined. We have recently demonstrated that silencing REG3β in a pancreatic cancer model impairs tumor growth by skewing macrophage polarization.

Keywords: :

• REG3β
• macrophage polarization
• pancreatic ductal adenocarcinoma

Citation: Folch-Puy E. Reg3β contributes to the immunosuppressive tumor microenvironment in pancreatic cancer. OncoImmunology 2013; 2:e26404; 10.4161/onci.26404

Disclosure of Potential Conflicts of Interest

There are no conflicts of interest to disclose.