Oxysterols recruit tumor-supporting neutrophils within the tumor microenvironment

Abstract

By binding to the liver X receptor (LXR), oxysterols inhibit the expression of chemokine (C-C motif) receptor 7 (CCR7), hence impairing the migration of dendritic cells to secondary lymphoid organs and inhibiting antitumor immune responses. We have recently identified a new tumor-supporting activity of oxysterols, which recruit neutrophils within tumor microenvironment by a chemokine (C-X-C motif) receptor 2 (CXCR2)-dependent, LXR-independent mechanism.

Keywords: :

• CXCR2
• immune evasion
• microenvironment
• oxysterols
• tumor-infiltrating neutrophils

Citation: Raccosta L, Fontana R, Traversari C, Russo V. Oxysterols recruit tumor-supporting neutrophils within the tumor microenvironment: The many facets of tumor-derived oxysterols. . OncoImmunology 2013; 2:e26469; 10.4161/onci.26469

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.