Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody

Abstract

Regulatory T cells (Tregs) play a central role in in tumor escape from immunosurveillance. We report that a bispecific T-cell engager (BiTE) targeting a mutated form of the epidermal growth factor receptor, i.e., EGFRvIII, potently redirects Tregs to kill glioblastoma through the granzyme-perforin pathway.

Keywords: :

• bispecific antibodies
• central nervous system neoplasms
• epidermal growth factor receptor
• glioblastoma
• granzymes
• regulatory T cells

Citation: Choi BD, Gedeon PC, Sanchez-Perez L, Bigner DD, Sampson JH. Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody. OncoImmunology 2013; 2:e26757; 10.4161/onci.26757

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.