OncoImmunology, Volume 2, Issue 12 (2013)

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OncoImmunology, Volume 2, Issue 12 (2013)

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Editorial

Editorial
Immunological effects of chemotherapy in spontaneous breast cancers
Guido Kroemer, Lorenzo Galluzzi & Laurence Zitvogel
Article: e27158
Published online: 14 Nov 2013
First Page PreviewforImmunological effects of chemotherapy in spontaneous breast cancers | Full Text | References | PDF (205.3 KB)
  • 778 Views
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Original Research

Article
CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells
Debbie C Strachan, Brian Ruffell, Yoko Oei, Mina J Bissell, Lisa M Coussens, Nancy Pryer & Dylan Daniel
Article: e26968
Published online: 04 Dec 2013
AbstractforCSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells | Full Text | References | PDF (1.5 MB) | Supplemental
  • 6785 Views
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Article
Helper cell-independent antitumor activity of potent CD8+ T cell epitope peptide vaccines is dependent upon CD40L
Diana Llopiz, Eduardo Huarte, Marta Ruiz, Jaione Bezunartea, Virginia Belsúe, Aintzane Zabaleta, Juan J Lasarte, Jesús Prieto, Francisco Borrás-Cuesta & Pablo Sarobe
Article: e27009
Published online: 05 Dec 2013
AbstractforHelper cell-independent antitumor activity of potent CD8+ T cell epitope peptide vaccines is dependent upon CD40L | Full Text | References | PDF (719.9 KB) | Supplemental
  • 742 Views
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Article
Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma
Karine Poussin, Camilla Pilati, Gabrielle Couchy, Julien Calderaro, Paulette Bioulac-Sage, Yannick Bacq, Valérie Paradis, Emmanuelle Leteurtre, Nathalie Sturm, Jeanne Ramos, Catherine Guettier, Armelle Bardier-Dupas, Anais Boulai, Dominique Wendum, Janick Selves, Tina Izard, Jean-Charles Nault & Jessica Zucman-Rossi
Article: e27090
Published online: 03 Jan 2014
AbstractforBiochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma | Full Text | References | PDF (771.2 KB) | Supplemental
  • 1301 Views
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Review

Review Article
Trial Watch
Peptide vaccines in cancer therapy
Fernando Aranda, Erika Vacchelli, Alexander Eggermont, Jérôme Galon, Catherine Sautès-Fridman, Eric Tartour, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi
Article: e26621
Published online: 04 Nov 2013
AbstractforTrial Watch | Full Text | References | PDF (426.9 KB)
  • 2250 Views
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Review Article
Immunosuppressants in cancer prevention and therapy
Mikhail V Blagosklonny
Article: e26961
Published online: 06 Nov 2013
AbstractforImmunosuppressants in cancer prevention and therapy | Full Text | References | PDF (465 KB)
  • 1453 Views
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Review Article
Role of TH17 cytokines in the control of colorectal cancer
Veronica De Simone, Francesco Pallone, Giovanni Monteleone & Carmine Stolfi
Article: e26617
Published online: 22 Oct 2013
AbstractforRole of TH17 cytokines in the control of colorectal cancer | Full Text | References | PDF (347.7 KB)
  • 1950 Views
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Review Article
Vaccine therapy for pancreatic cancer
Bulent Salman, Donger Zhou, Elizabeth M Jaffee, Barish H Edil & Lei Zheng
Article: e26662
Published online: 22 Oct 2013
AbstractforVaccine therapy for pancreatic cancer | Full Text | References | PDF (374.5 KB)
  • 2952 Views
  • 39 CrossRef citations
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Review Article
Characteristics of tertiary lymphoid structures in primary cancers
Jérémy Goc, Wolf-Herman Fridman, Catherine Sautès-Fridman & Marie-Caroline Dieu-Nosjean
Article: e26836
Published online: 22 Oct 2013
AbstractforCharacteristics of tertiary lymphoid structures in primary cancers | Full Text | References | PDF (613.3 KB)
  • 3350 Views
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Review Article
Harnessing the antitumor potential of macrophages for cancer immunotherapy
Kristen B Long & Gregory L Beatty
Article: e26860
Published online: 04 Nov 2013
AbstractforHarnessing the antitumor potential of macrophages for cancer immunotherapy | Full Text | References | PDF (628.7 KB)
  • 2041 Views
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Review Article
Combining low-dose or metronomic chemotherapy with anticancer vaccines
A therapeutic opportunity for lymphomas
Heng Sheng Sow & Stephen R Mattarollo
Article: e27058
Published online: 05 Nov 2013
AbstractforCombining low-dose or metronomic chemotherapy with anticancer vaccines | Full Text | References | PDF (724.2 KB)
  • 1063 Views
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Review Article
How to exploit stress-related immunity against Hodgkin’s lymphoma
Targeting ERp5 and ADAM sheddases
Alessandro Poggi & Maria Raffaella Zocchi
Article: e27089
Published online: 05 Dec 2013
AbstractforHow to exploit stress-related immunity against Hodgkin’s lymphoma | Full Text | References | PDF (593.2 KB)
  • 1104 Views
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Review Article
Immunopathogenesis of paraneoplastic neurological syndromes associated with anti-Hu antibodies
A beneficial antitumor immune response going awry
Béatrice SL Pignolet, Christina MT Gebauer & Roland S Liblau
Article: e27384
Published online: 10 Dec 2013
AbstractforImmunopathogenesis of paraneoplastic neurological syndromes associated with anti-Hu antibodies | Full Text | References | PDF (561.4 KB)
  • 2097 Views
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Author's View

Modifying tumor-associated macrophages
An important adjunct to immunotherapy
Zvi G Fridlender & Steven M Albelda
Article: e26620
Published online: 21 Oct 2013
AbstractforModifying tumor-associated macrophages | Full Text | References | PDF (299.6 KB)
  • 719 Views
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KIR/HLA immunogenetic background influences the evolution of hepatocellular carcinoma
Elisabetta Cariani & Gabriele Missale
Article: e26622
Published online: 21 Oct 2013
AbstractforKIR/HLA immunogenetic background influences the evolution of hepatocellular carcinoma | Full Text | References | PDF (305.2 KB)
  • 574 Views
  • 11 CrossRef citations
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Open Access
Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma
Alessandra Soriani, Cinzia Fionda, Biancamaria Ricci, Maria Luisa Iannitto, Marco Cippitelli & Angela Santoni
Article: e26663
Published online: 22 Oct 2013
AbstractforChemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma | Full Text | References | PDF (318.3 KB)
  • 1096 Views
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High-affinity peptide-based anticancer vaccination to overcome resistance to immunostimulatory antibodies
David C Binder & Hans Schreiber
Article: e26704
Published online: 22 Oct 2013
AbstractforHigh-affinity peptide-based anticancer vaccination to overcome resistance to immunostimulatory antibodies | Full Text | References | PDF (253.5 KB)
  • 690 Views
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Open Access
EGFR-mediated tumor immunoescape
The imbalance between phosphorylated STAT1 and phosphorylated STAT3
Fernando Concha-Benavente, Raghvendra M Srivastava, Soldano Ferrone & Robert L Ferris
Article: e27215
Published online: 05 Dec 2013
AbstractforEGFR-mediated tumor immunoescape | Full Text | References | PDF (340.9 KB)
  • 1195 Views
  • 31 CrossRef citations
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When breast cancer cells start to fend the educational process of NK cells off
Emilie Mamessier, Charlotte Bourgin & Daniel Olive
Article: e26688
Published online: 22 Oct 2013
AbstractforWhen breast cancer cells start to fend the educational process of NK cells off | PDF (328.1 KB)
  • 258 Views
  • 9 CrossRef citations
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Impact of STAT1 and CD8+ T cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors
Piotr Tymoszuk & Wolfgang Doppler
Article: e26689
Published online: 22 Oct 2013
AbstractforImpact of STAT1 and CD8+ T cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors | PDF (479.9 KB)
  • 180 Views
  • 2 CrossRef citations
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Open Access
A2A blockade enhances anti-metastatic immune responses
Paul A Beavis, Nicole Milenkovski, John Stagg, Mark J Smyth & Phillip K Darcy
Article: e26705
Published online: 22 Oct 2013
AbstractforA2A blockade enhances anti-metastatic immune responses | Full Text | References | PDF (287.1 KB)
  • 2275 Views
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Disarmed by density
A glycolytic break for immunostimulatory dendritic cells?
Aikaterini Nasi & Bence Rethi
Article: e26744
Published online: 22 Oct 2013
AbstractforDisarmed by density | Full Text | References | PDF (259.5 KB)
  • 522 Views
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Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody
Bryan D Choi, Patrick C Gedeon, Luis Sanchez-Perez, Darell D Bigner & John H Sampson
Article: e26757
Published online: 22 Oct 2013
AbstractforRegulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody | Full Text | References | PDF (227.5 KB)
  • 1294 Views
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TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity
Marc Cartellieri, Claudia Arndt, Anja Feldmann, Malte von Bonin, Eva-Maria Ewen, Stefanie Koristka, Irene Michalk, Slava Stamova, Nicole Berndt, Anne Gocht, Martin Bornhäuser, Gerhard Ehninger, Marc Schmitz & Michael Bachmann
Article: e26770
Published online: 22 Oct 2013
AbstractforTCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity | Full Text | References | PDF (244.5 KB)
  • 783 Views
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The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration
Jennifer Watt & Hemant M Kocher
Article: e26788
Published online: 22 Oct 2013
AbstractforThe desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration | Full Text | References | PDF (328.5 KB)
  • 1426 Views
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Macrophage-based immunotherapy for the treatment of pancreatic ductal adenocarcinoma
Gregory L Beatty
Article: e26837
Published online: 22 Oct 2013
AbstractforMacrophage-based immunotherapy for the treatment of pancreatic ductal adenocarcinoma | Full Text | References | PDF (336.8 KB)
  • 679 Views
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Targeting inflammatory cytokines-androgen receptor (AR) signaling with ASC-J9® to better battle prostate cancer progression
Kouji Izumi & Chawnshang Chang
Article: e26853
Published online: 22 Oct 2013
AbstractforTargeting inflammatory cytokines-androgen receptor (AR) signaling with ASC-J9® to better battle prostate cancer progression | Full Text | References | PDF (324.9 KB)
  • 874 Views
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A novel recombinant immunotoxin-based therapy targeting wild-type and mutant EGFR improves survival in murine models of glioblastoma
Vidyalakshmi Chandramohan & Darell D Bigner
Article: e26852
Published online: 22 Oct 2013
AbstractforA novel recombinant immunotoxin-based therapy targeting wild-type and mutant EGFR improves survival in murine models of glioblastoma | Full Text | References | PDF (184.4 KB)
  • 673 Views
  • 9 CrossRef citations
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Linking oncogenesis and immune system evasion in acquired resistance to EGFR-targeting antibodies
Lessons from a preclinical model
Greta Garrido, Ailem Rabasa & Belinda Sánchez
Article: e26904
Published online: 06 Nov 2013
AbstractforLinking oncogenesis and immune system evasion in acquired resistance to EGFR-targeting antibodies | Full Text | References | PDF (214.4 KB)
  • 420 Views
  • 3 CrossRef citations
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β-catenin-mediated inhibition of cross-priming
A new mechanism for tumors to evade immunosurveillance
Chunmei Fu & Aimin Jiang
Article: e26920
Published online: 06 Nov 2013
Abstractforβ-catenin-mediated inhibition of cross-priming | Full Text | References | PDF (241.2 KB)
  • 480 Views
  • 3 CrossRef citations
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Attacking malignant cells that survive therapy
Exploiting immunogenic modulation
James W Hodge, Anna Kwilas, Andressa Ardiani & Sofia R Gameiro
Article: e26937
Published online: 06 Nov 2013
AbstractforAttacking malignant cells that survive therapy | Full Text | References | PDF (688 KB)
  • 687 Views
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Dendritic cell-based immunotherapy in ovarian cancer
An Coosemans, Ignace Vergote & Stefaan W Van Gool
Article: e27059
Published online: 06 Nov 2013
AbstractforDendritic cell-based immunotherapy in ovarian cancer | Full Text | References | PDF (167.6 KB)
  • 747 Views
  • 10 CrossRef citations
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Alerting the immune system via stromal cells is central to the prevention of tumor growth
Shohreh Issazadeh-Navikas
Article: e27091
Published online: 11 Nov 2013
AbstractforAlerting the immune system via stromal cells is central to the prevention of tumor growth | Full Text | References | PDF (347.1 KB)
  • 504 Views
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Rewiring cancer cell death to enhance oncolytic viro-immunotherapy
Samuel T Workenhe & Karen L Mossman
Article: e27138
Published online: 09 Dec 2013
AbstractforRewiring cancer cell death to enhance oncolytic viro-immunotherapy | Full Text | References | PDF (348.5 KB)
  • 800 Views
  • 20 CrossRef citations
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Impact of aging in cancer immunotherapy
The importance of using accurate preclinical models
Myriam N Bouchlaka & William J Murphy
Article: e27186
Published online: 09 Dec 2013
AbstractforImpact of aging in cancer immunotherapy | Full Text | References | PDF (564.9 KB)
  • 647 Views
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Finding a needle in a haystack
Activation-induced CD137 expression accurately identifies naturally occurring tumor-reactive T cells in cancer patients
Qunrui Ye, De-Gang Song & Daniel J Powell Jr
Article: e27184
Published online: 09 Dec 2013
AbstractforFinding a needle in a haystack | Full Text | References | PDF (354.4 KB)
  • 892 Views
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Imaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation
Daniel H Madsen & Thomas H Bugge
Article: e27127
Published online: 09 Dec 2013
AbstractforImaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation | Full Text | References | PDF (479.3 KB)
  • 1217 Views
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Acute myeloid leukemia therapeutics
CARs in the driver’s seat
Armen Mardiros, Christine E Brown, L Elizabeth Budde, Xiuli Wang & Stephen J Forman
Article: e27214
Published online: 09 Dec 2013
AbstractforAcute myeloid leukemia therapeutics | Full Text | References | PDF (246.7 KB)
  • 1120 Views
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Macrophages increase the resistance of pancreatic adenocarcinoma cells to gemcitabine by upregulating cytidine deaminase
Moran Amit & Ziv Gil
Article: e27231
Published online: 10 Dec 2013
AbstractforMacrophages increase the resistance of pancreatic adenocarcinoma cells to gemcitabine by upregulating cytidine deaminase | Full Text | References | PDF (240 KB)
  • 1026 Views
  • 39 CrossRef citations
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The perioperative immune/inflammatory insult in cancer surgery
Time for intervention?
Campbell S Roxburgh, Paul G Horgan & Donald C McMillan
Article: e27324
Published online: 09 Dec 2013
AbstractforThe perioperative immune/inflammatory insult in cancer surgery | Full Text | References | PDF (429.8 KB)
  • 752 Views
  • 24 CrossRef citations
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Interferon α interferes with immunological tolerance
Christian Becker, Tobias Bopp & Kerstin Steinbrink
Article: e27528
Published online: 03 Jan 2014
AbstractforInterferon α interferes with immunological tolerance | Full Text | References | PDF (313.4 KB)
  • 546 Views
  • 5 CrossRef citations
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Invariant NKT cells
Killers and conspirators against cancer
Hamid Bassiri, Rupali Das & Kim E Nichols
Article: e27440
Published online: 03 Jan 2014
AbstractforInvariant NKT cells | Full Text | References | PDF (293.1 KB)
  • 696 Views
  • 18 CrossRef citations
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