Modulating antigen processing for cancer immunotherapy

Abstract

The intracellular aminopeptidases that process antigenic epitopes have been recently shown to be valid targets for eliciting cell-mediated antitumor immune responses. Here, we discuss the recent development of potent, low molecular weight inhibitors of these enzymes and how such compounds may constitute a promising tool for cancer immunotherapy.

Keywords: :

• antigen
• inhibitor
• enzyme
• peptide
• presentation
• cytotoxicity
• immunotherapy
• epitope

Citation: Stratikos E. Modulating antigen processing for cancer immunotherapy. OncoImmunology 2013; 2:e27568; 10.4161/onci.27568

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.