Myeloid-derived cells are key targets of tumor immunotherapy

Abstract

Tumors are composed of heterogeneous cell populations recruited by cancer cells to promote growth and metastasis. Among cells comprising the tumor stroma, myeloid-derived cells play pleiotropic roles in supporting tumorigenesis at distinct stages of tumor development. The tumor-infiltrating myeloid cell contingent is composed of mast cells, neutrophils, dendritic cells, macrophages, and myeloid-derived suppressor cells. Such cells are capable of evading the hostile tumor environment typically prone to immune cell destruction and can even promote angiogenesis, chronic inflammation, and invasion. This paper briefly summarizes the different myeloid-derived subsets that promote tumor development and the strategies that have been used to counteract the protumorigenic activity of these cells. These strategies include myeloid cell depletion, reduction of recruitment, and inactivation or remodeling of cell phenotype. Combining drugs designed to target tumor myeloid cells with immunotherapies that effectively trigger antitumor adaptive immune responses holds great promise in the development of novel cancer treatments.

Keywords: :

• myeloid-derived suppressor cells
• tumor-associated macrophages
• tumor-associated neutrophils
• dendritic cells
• immunotherapy

Citation: Medina-Echeverz J, Aranda F, Berraondo P. Myeloid-derived cells are key targets of tumor immunotherapy. OncoImmunology 2014; 3:e28398; 10.4161/onci.28398

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Acknowledgments

This work was supported by “Fondo de Investigaciones Sanitarias,” “Fundación Mutua Madrileña” and by the agreement between “Fundación para la Investigación Médica Aplicada” and the “Unión Temporal de Empresas proyecto Centro de Investigación Médica Aplicada.” J.M.E. was supported by a fellowship of “Fondo de Investigaciones Sanitarias.” P.B. was supported by a Miguel Servet contract from “Fondo de Investigaciones Sanitarias.”