Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages

Abstract

In gastrointestinal stromal tumor (GIST), the most common human sarcoma, tumor-associated macrophages (TAMs) have been found to be abundant and surprisingly M1-like, exhibiting antitumoral activities. However, TAMs switch to M2-like during the course of imatinib therapy, but upon drug resistance TAMs revert to M1-like. Therefore, the oncologic efficacy of TAM depletion may depend on tumor type and treatment status.

Keywords: :

• C/EBPβ
• CSF1R
• gastrointestinal stromal tumor
• macrophage
• tumor-associated macrophage

Citation: Cavnar MJ, DeMatteo RP. Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages. OncoImmunology 2014; 3:e28463; 10.4161/onci.28463

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.