Discovering cancer immunotherapy targets in vivo

Abstract

A key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery of such targets in the tumor microenvironment in vivo utilizing pooled shRNA libraries as a screening tool. Here, we discuss applying this unbiased method to develop innovative cancer therapeutics.

Keywords: :

• cancer
• T cell
• therapeutic targets
• RNAi screen
• tumor microenvironment

Citation: Zhou P, Wucherpfennig KW. Discovering cancer immunotherapy targets in vivo. OncoImmunology 2014; 3:e28500; 10.4161/onci.28500

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.