Mfd as a central partner of transcription coupled repair

Abstract

Transcription-coupled repair (TCR) is one of the key of the nucleotide excision repair (NER) pathways required to preserve genome integrity. Although understanding TCR is still a major challenge, recent single-molecule experiments have brought new insights into the initial steps of TCR leading to new perspectives.

Keywords: :

• DNA repair
• Mfd
• nucleotide excision repair (NER)
• single-molecule
• stalled RNAp
• transcription-coupled repair (TCR)

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Acknowledgments

JM is founded by the AVIESAN ITMO Cancer Consortium through Frontières du Vivant (FdV) PhD program. WG is founded by University of Paris Diderot (Paris VII). NJ and TRS are founded by CNRS. The lab is supported by CNRS, University of Paris Diderot (Paris VII), with a core funding by a EURYI grant to TRS. We apologize for all the references that we were not able to cite due to the space limitation.