Abstract
Staphylococcus aureus is a major human pathogen associated with nosocomial and community-acquired infections, and is also responsible for several economically important infections of livestock. However, the evolutionary origin of animal strains and the potential for cross-species transmission has not been well examined. We recently traced the origin of a common S. aureus clone which is a significant cause of morbidity in the global broiler poultry industry. We provided evidence that it evolved from a single human to poultry host jump which was followed by extensive genetic diversification including acquisition of novel mobile genetic elements and loss of virulence gene function. The clone has since been disseminated widely to several different continents presumably through globalization of the poultry industry. In the current article, we summarise the findings of the paper, discuss their implications and speculate on the potential for other S. aureus cross-species transfer events.